中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2010年
10期
912-914
,共3页
郭娟%陈元堂%何长江%张丽%吴瑜%行养玲%敖磊
郭娟%陳元堂%何長江%張麗%吳瑜%行養玲%敖磊
곽연%진원당%하장강%장려%오유%행양령%오뢰
精神分裂症%锚蛋白重复和激酶域1%多态性%关联分析
精神分裂癥%錨蛋白重複和激酶域1%多態性%關聯分析
정신분렬증%묘단백중복화격매역1%다태성%관련분석
Schizophrenia%Ankyrin repeat and kinase domain containing 1%Polymorphism%Association analysis
目的 探讨锚蛋白重复和激酶域1(ANKK1)基因多态性与精神分裂症的相关性.方法 收集符合美国DSM-Ⅳ精神分裂症诊断标准的112个先证者及其父母组成的核心家系,运用聚合酶链反应扩增及单核苷酸多态性的分子生物学技术,对ANK K1基因的rs4938015、rs7118900、rs2734849、rs1800497多态性分型,进行精神分裂症与锚蛋白重复和激酶域1基因多态性的关联分析和单体型相对风险率分析.结果 rs2734849等位基因与精神分裂症相关联(P=0.026),其中等位基因T是保护因素(Z=-2.19),A为危险因素(Z=2.19);rs4938015、rs7118900、rs1800497与精神分裂症无关联.三种单体型rs7118900-rs2734849的G/A、rs 2734849-rs1800497的A/C、rs7118900-rs2734849-rs1800497中的G/A/C与精神分裂症有关联(P值分别为0.032,0.041,0.046,基因型频率分别为0.36,0.29,0.17).结论 ANKK1基因与精神分裂症相关联.
目的 探討錨蛋白重複和激酶域1(ANKK1)基因多態性與精神分裂癥的相關性.方法 收集符閤美國DSM-Ⅳ精神分裂癥診斷標準的112箇先證者及其父母組成的覈心傢繫,運用聚閤酶鏈反應擴增及單覈苷痠多態性的分子生物學技術,對ANK K1基因的rs4938015、rs7118900、rs2734849、rs1800497多態性分型,進行精神分裂癥與錨蛋白重複和激酶域1基因多態性的關聯分析和單體型相對風險率分析.結果 rs2734849等位基因與精神分裂癥相關聯(P=0.026),其中等位基因T是保護因素(Z=-2.19),A為危險因素(Z=2.19);rs4938015、rs7118900、rs1800497與精神分裂癥無關聯.三種單體型rs7118900-rs2734849的G/A、rs 2734849-rs1800497的A/C、rs7118900-rs2734849-rs1800497中的G/A/C與精神分裂癥有關聯(P值分彆為0.032,0.041,0.046,基因型頻率分彆為0.36,0.29,0.17).結論 ANKK1基因與精神分裂癥相關聯.
목적 탐토묘단백중복화격매역1(ANKK1)기인다태성여정신분렬증적상관성.방법 수집부합미국DSM-Ⅳ정신분렬증진단표준적112개선증자급기부모조성적핵심가계,운용취합매련반응확증급단핵감산다태성적분자생물학기술,대ANK K1기인적rs4938015、rs7118900、rs2734849、rs1800497다태성분형,진행정신분렬증여묘단백중복화격매역1기인다태성적관련분석화단체형상대풍험솔분석.결과 rs2734849등위기인여정신분렬증상관련(P=0.026),기중등위기인T시보호인소(Z=-2.19),A위위험인소(Z=2.19);rs4938015、rs7118900、rs1800497여정신분렬증무관련.삼충단체형rs7118900-rs2734849적G/A、rs 2734849-rs1800497적A/C、rs7118900-rs2734849-rs1800497중적G/A/C여정신분렬증유관련(P치분별위0.032,0.041,0.046,기인형빈솔분별위0.36,0.29,0.17).결론 ANKK1기인여정신분렬증상관련.
Objective To detect the genetic association between schizophrenia and polymorphism of Ankyrin repeat and kinase domain containing 1 ( ANKK1 ) gene. Methods Observed in a sample of 112 parent/offspring trios where the proband net the American Classification and diagnostic Criteria for Mental Disorders The Forth Revised Edition, criteria for schizophrenia using correlation analysis and haplotype relative risk analysis. The polymorphism of Ankyrin repeat and kinase domain containing 1 gene was detected with PCR methods and SNP typing in all nucleus families. Results The rs2734849 allele was connected with schizophrenia(P= 0. 026). Allele T was protective factor( Z= -2.19) and allele A was the hazard factor( Z=2. 19). The rs4938015,rs7118900 and rs1800497 allele were independence with schizophrenia. Three kinds haplotypes of G/A in the rs7118900 -rs2734849, A/C in the rs2734849 -rs1800497, G/A/C in the rs7118900 -rs2734849 -rs1800497 were associated with schizophrenia ( The P values were 0.032,0. 041,0.046, the genotype frequencies were 0. 36,0.29,0. 17 ).Conclusion It shows an association between schizophrenia and the polymorphism at nucleotide of ankyrin repeat and kinase domain containing 1 gene in Chinese.
