CAJ | 학술논문

目的了解天津市3～6岁儿童血脂水平和血脂异常检出率.方法采集天津市48所幼儿园20041名3～6岁儿童末梢血,采用东芝120全自动生化分析仪检测血浆总胆固醇(TC)和甘油三酯(TG)水平.结果 20 041名入托儿童TC和TG分别为(4.17±0.69) mmol/L和(0.86±0.44) mmol/L；血脂异常总检出率为11.4％,其中TC异常检出率为7.1％,TG为4.9％,两项均异常的检出率为0.6％.不同性别儿童TC异常检出率女童高于男童,差异有统计学意义(x2=51.77,P＜0.001).不同年龄组儿童TC和TG异常检出率的差异均有统计学意义(x2=10.29,P=0.016；x2=10.93,P=0.012),但未见明显的年龄变化趋势.不同肥胖程度儿童TC异常检出率的差异无统计学意义,TG异常检出率差异有统计学意义(x2=211.8,P＜0.001),肥胖儿童TG异常检出率明显高于正常和超重儿童.城乡地区儿童TC和TG异常检出率差异均有统计学意义(x2=22.09,P＜0.001；x2=11.26,P=0.001),TC异常检出率城市儿童高于农村,TG异常检出率农村儿童高于城市.结论天津市3～6岁儿童血脂异常率较高,且存在性别、年龄、肥胖程度、地区差异,应有针对性开展儿童血脂异常筛查与干预.
목적 료해천진시3～6세인동혈지수평화혈지이상검출솔.방법 채집천진시48소유인완20041명3～6세인동말소혈,채용동지120전자동생화분석의검측혈장총담고순(TC)화감유삼지(TG)수평.결과 20 041명입탁인동TC화TG분별위(4.17±0.69) mmol/L화(0.86±0.44) mmol/L；혈지이상총검출솔위11.4％,기중TC이상검출솔위7.1％,TG위4.9％,량항균이상적검출솔위0.6％.불동성별인동TC이상검출솔녀동고우남동,차이유통계학의의(x2=51.77,P＜0.001).불동년령조인동TC화TG이상검출솔적차이균유통계학의의(x2=10.29,P=0.016；x2=10.93,P=0.012),단미견명현적년령변화추세.불동비반정도인동TC이상검출솔적차이무통계학의의,TG이상검출솔차이유통계학의의(x2=211.8,P＜0.001),비반인동TG이상검출솔명현고우정상화초중인동.성향지구인동TC화TG이상검출솔차이균유통계학의의(x2=22.09,P＜0.001；x2=11.26,P=0.001),TC이상검출솔성시인동고우농촌,TG이상검출솔농촌인동고우성시.결론 천진시3～6세인동혈지이상솔교고,차존재성별、년령、비반정도、지구차이,응유침대성개전인동혈지이상사사여간예.
Objective To understand the level of blood-lipid and prevalence of dyslipidcmia of children aged 3 to 6 in Tianjin,so as to provide evidence for large-scale blood screening strategy and to develop intervention of dyslipidemia and cardiovascular in children.Methods 20 041 children aged 3 to 6 from 48 kindergartens were involved in this study,in Tianjin.Peripheral blood was collected from right leech-finger of these children,after fatless breakfast.Total cholesterol (TC) and triglyceride (TG) of plasma were tested using Toshiba 120 Automatic Biochemical Analyzer.Results The average levels of TC and TG were (4.17 ±0.69)mmol/L and (0.86±0.44) mmol/L in these children.11.4％ of the children had either TC or TG dyslipidemia,with 7.1％ had only TC dyslipidemia,4.9％ had only TG dyslipidemia,and 0.6％ of them had both TC and TG dyslipidemia.The prevalence of TC dyslipidemia was significantly higher among girls than boys.The prevalence rates of TC dyslipidemia and TG dyslipidcmia were different among age groups,but with no significant changes among age groups.The prevalence of TG dyslipidemia was significantly different,with obese children higher than those with normal or overweight children.Different residential areas seemed to be related to the difference on the prevalence of dyslipidemia.Prevalence of TC dyslipidemia was higher in urban than in rural areas.Prevalence of TG dyslipidemia was higher in rural than urban areas.Conclusion The prevalence of dyslipidemia for children aged 3 to 6 was high in Tianjin,and showed differences among genders,age groups and residential regions.Screening and intervention programs on dyslipidemia should be undertaken routinely in children,in order to prevent adult atherosclerosis and coronary heart disease.