CAJ | 학술논문

目的探讨脑出血大鼠血清白蛋白水平与空肠黏膜形态学之间的关系.寻找导致低蛋白血症的机制.方法制作脑出血大鼠模型.检测正常对照组、假手术组及脑出血组术后1、7、14 d(每组8只)血清白蛋白水平与空肠黏膜形态学的参数.进行血清白蛋白水平与空肠黏膜形态学的参数值之间的相关分析.结果血清白蛋白与小肠绒毛高度(r=0.869,P＜0.01)、绒毛面积(r=0.659,P＜0.01)、黏膜厚度(r=0.915,P＜0.01)、肠腺深度(r=0.545,P＜0.05)及肠腺密度(r=0.475,P＜0.05)呈正相关.结论血清白蛋白水平与空肠黏膜形态学变化的关系密切.
목적 탐토뇌출혈대서혈청백단백수평여공장점막형태학지간적관계.심조도치저단백혈증적궤제.방법 제작뇌출혈대서모형.검측정상대조조、가수술조급뇌출혈조술후1、7、14 d(매조8지)혈청백단백수평여공장점막형태학적삼수.진행혈청백단백수평여공장점막형태학적삼수치지간적상관분석.결과 혈청백단백여소장융모고도(r=0.869,P＜0.01)、융모면적(r=0.659,P＜0.01)、점막후도(r=0.915,P＜0.01)、장선심도(r=0.545,P＜0.05)급장선밀도(r=0.475,P＜0.05)정정상관.결론 혈청백단백수평여공장점막형태학변화적관계밀절.
Objective To explore the correlation between the serum albumin level and the jejunal mucosal morphology in rats with cerebral hemorrhage and to find out the mechanism of the resulting hypoproteinemia.Methods A rat model of cerebral hemorrhage was used to detect the serum albumin level and the morphologic parameters of jejunal mucosa on day 1,7 and 14 after the hemorrhage.The results were compared to the normal control group and the sham-operated group. The correlation between the serum albumin level and the parameters of the jejunal mucosal morphology was explored.Results The serum albumin level was positively correlated with the small intestinal villous height(r =0.869,P＜0.01),villous area(r=0.659,P＜0.01),mucosal thickness (r=0.915,P＜0.01),depth of intestinal glands(r=0.545,P＜0.05)and density of intestinal glands(r=0.475,P＜0.05).Conclusion The serum albumin level is closely related to the morphologic changes of the jejunal mucosa.