CAJ | 학술논문

目的探讨紫杉醇单药同步调强放疗治疗食管癌的近期疗效、局部控制率、生存率及不良反应.方法 103例食管癌患者根据入选标准随机分组,60例进入调强放疗+紫杉醇组(放化组),43例进入单纯调强放疗组(单放组).单放组采用调强放疗,95％ PTV:66GY/30 ～ 33次,每周5次；放化组放疗从第1天即开始采用调强放射治疗,同时化疗(紫杉醇30 mg),第1、8、15、22、29、36天静脉滴注.结果局部近期疗效放化组好于单放组,两组比较差异有统计学意义(P＜0.05).放化疗组与单放组1、2年生存率,单放组为55.8％( 24/43)、32.5％( 14/43),同步放化组为86.6％ (52/60)、68.3％ (41/60).两组比较差异有统计学意义(P＜0.05).不良反应放化组稍高于单放组,但两者比较差异无统计学意义.结论紫杉醇单药每周方案同步调强放疗治疗食管癌近期疗效和局部控制率较好,能提高远期生存率,虽不良反应增加但能耐受.
목적 탐토자삼순단약동보조강방료치료식관암적근기료효、국부공제솔、생존솔급불량반응.방법 103례식관암환자근거입선표준수궤분조,60례진입조강방료+자삼순조(방화조),43례진입단순조강방료조(단방조).단방조채용조강방료,95％ PTV:66GY/30 ～ 33차,매주5차；방화조방료종제1천즉개시채용조강방사치료,동시화료(자삼순30 mg),제1、8、15、22、29、36천정맥적주.결과 국부근기료효방화조호우단방조,량조비교차이유통계학의의(P＜0.05).방화료조여단방조1、2년생존솔,단방조위55.8％( 24/43)、32.5％( 14/43),동보방화조위86.6％ (52/60)、68.3％ (41/60).량조비교차이유통계학의의(P＜0.05).불량반응방화조초고우단방조,단량자비교차이무통계학의의.결론 자삼순단약매주방안동보조강방료치료식관암근기료효화국부공제솔교호,능제고원기생존솔,수불량반응증가단능내수.
Objective To evaluate the short- term efficacy,local control rates,survival rates and toxicity of concurrent paclitaxel chemotherapy and IMRT for esophageal carcinoma.Methods One hundred and three cases esophageal carcinoma patients were randomized in to two groups,60 cases was treated with concurrent IMCRT and paclitaxel chemotherapy ( named chemo - radiation group),another 43 cases with radiotherapy only (named radiotherapy group).All patients were irradiation 2.0 Gy/per fraction by planning target volume (PTV) 95 ％,five fractions a week,the total radiation dose was 66 Gy in tumor.Besides,the chemo - radistion group was also received the concurrent chemotherapy with 60 mg of paclitaxel every Monday when radiation.Results The chemo -radiation group was more effective than radiotherapy group,and there was significant difference between the 2 groups (P ＜ 0.05 ). 1 -year,2 - year survival rates of chemo - radiation group and radiation group were 86.6％,68.3％ and 55.8％,32.5％,respectively,and there were significant differences between the two groups.Conclusions Concurrent paclitaxel chemotherapy and intensity modulated radiation therapy (IMRT) for esophageal carcinoma can improve the short- term efficacy and local control rate,and hence improve the longterm survival rate with lightly higher and tolerable toxicity.