CAJ | 학술논문

以0、50、100、200mg/kg bw·d的茶氨酸剂量灌胃小鼠,30d后进行睡眠功能性评价实验.结果表明,茶氨酸具有改善睡眠的功效,中剂量组(100mg/kg bw·d)的各项功能性评价效果最佳.茶氨酸没有直接的催眠作用,但能有效延长戊巴比妥钠催眠条件下小鼠的睡眠时间[中剂量组的睡眠时间为(40.3±26.0)min],提高巴比妥钠阈下剂量催眠条件下小鼠的入睡率(中剂量组的入睡率达33.3%)以及有效缩短巴比妥钠催眠条件下小鼠的睡眠潜伏期[中剂量组的睡眠潜伏期为(30.32±4.8)min],与空白组相比差异显著.
이0、50、100、200mg/kg bw·d적다안산제량관위소서,30d후진행수면공능성평개실험.결과표명,다안산구유개선수면적공효,중제량조(100mg/kg bw·d)적각항공능성평개효과최가.다안산몰유직접적최면작용,단능유효연장무파비타납최면조건하소서적수면시간[중제량조적수면시간위(40.3±26.0)min],제고파비타납역하제량최면조건하소서적입수솔(중제량조적입수솔체33.3%)이급유효축단파비타납최면조건하소서적수면잠복기[중제량조적수면잠복기위(30.32±4.8)min],여공백조상비차이현저.
The effects of L-theanine on barbiturate-induced sleeping tirade, subthreshold barbiturate-induced sleeping time and barbiturate-induced sleeping latency period in mice were investigate. Healthy ICR mice were randomly divided into four groups of 12 mice each: control group fed with distilled water and three treatment groups fed L-theanine at low-, medium-, and high- and the best effect was found in the medium-dose-treated mice. However, no direct hypnotic effect of L-theanine was observed while it was able to prolong the sleeping time induced by pentobarbital sodium [that of the medium-dose-treated mice reached (40.3±26.0) min] and to enhance the sleeping rate induced by barbital sodium at the threshold dose (that of the medium-dose- treated mice reached 33.3 %). L-Theanine also eoald significantly decrease (P < 0.05) the sleeping latency period induced by barbital sodium [that of the medium-dose-treated mice reached (30.32±4.8) min].