浙江大学学报（医学版）
浙江大學學報（醫學版）
절강대학학보（의학판）
JOURNAL OF ZHEJIANG UNIVERSITY MEDICAL SCIENCES
2009年
6期
649-654
,共6页
结构同源性%蛋白质%PICK1%PDZ结构域%BAR结构域%中枢神经系统疾病
結構同源性%蛋白質%PICK1%PDZ結構域%BAR結構域%中樞神經繫統疾病
결구동원성%단백질%PICK1%PDZ결구역%BAR결구역%중추신경계통질병
Structural homology%protein%PICK1%PDZ domain%BAR domain%Central nervous system disease
PICK1(protein interacting with C kinase 1)是一种含PDZ(PSD-95/Dlg/ZO1)结构域和BAR (Bin/amphiphysin/Rvs)结构域的蛋白,它可通过PDZ结构域与多种蛋白发生相互作用,其中一些蛋白与中枢神经系统(CNS)疾病密切相关.文中综述了近年来关于PICK1在几种中枢神经系统疾病中的作用研究,以期对疾病研究和临床治疗提供参考.
PICK1(protein interacting with C kinase 1)是一種含PDZ(PSD-95/Dlg/ZO1)結構域和BAR (Bin/amphiphysin/Rvs)結構域的蛋白,它可通過PDZ結構域與多種蛋白髮生相互作用,其中一些蛋白與中樞神經繫統(CNS)疾病密切相關.文中綜述瞭近年來關于PICK1在幾種中樞神經繫統疾病中的作用研究,以期對疾病研究和臨床治療提供參攷.
PICK1(protein interacting with C kinase 1)시일충함PDZ(PSD-95/Dlg/ZO1)결구역화BAR (Bin/amphiphysin/Rvs)결구역적단백,타가통과PDZ결구역여다충단백발생상호작용,기중일사단백여중추신경계통(CNS)질병밀절상관.문중종술료근년래관우PICK1재궤충중추신경계통질병중적작용연구,이기대질병연구화림상치료제공삼고.
PICK1 (protein interacting with C kinase 1) contains a PDZ (PSD-95/Dlg/ZO1) domain and a BAR (Bin/amphiphysin/Rvs) domain.Via the PDZ domain,PICK1 interacts directly with more than 40 proteins.Among these interacting proteins,some are important for physiological and pathophysiological processes of central nervous system.In this review,recent findings about how PICK1 is associated with central nervous system diseases are summarize.
