CAJ | 학술논문

研究深入的神经调控机制、定量的行为检测指标以及成熟的研究范式可能会使快速跳视(saccade)在精神疾病研究和临床诊断中发挥重要作用.理论上讲,它不仅可以帮助研究者寻找神经系统病变早期的特异性检测指标,而且能成为新药开发与药效评价的衡量标准.帕金森病、老年痴呆与抑郁症患者都存在快速跳视的控制异常,然而这些异常是如何发展变化以及怎样排除患者个体差异的影响一直是研究工作进一步深入的绊脚石,建立猕猴精神疾病模犁并在建模过程中不断监测快速跳视各项指标的变化可能会帮我们找到疾病早期病变检测的特异指标并为临床新药的开发搭建药效评价的平台.
연구심입적신경조공궤제、정량적행위검측지표이급성숙적연구범식가능회사쾌속도시(saccade)재정신질병연구화림상진단중발휘중요작용.이론상강,타불부가이방조연구자심조신경계통병변조기적특이성검측지표,이차능성위신약개발여약효평개적형량표준.파금삼병、노년치태여억욱증환자도존재쾌속도시적공제이상,연이저사이상시여하발전변화이급즘양배제환자개체차이적영향일직시연구공작진일보심입적반각석,건립미후정신질병모리병재건모과정중불단감측쾌속도시각항지표적변화가능회방아문조도질병조기병변검측적특이지표병위림상신약적개발탑건약효평개적평태.
Saceades may play an important role in mental disorders research and diagnosis. Not only can saccade be used to help researchers to acquire the early and specific neuropathological changes, but also be a criterion of new drug development and drug efficacy tests. Abnormalities of saecadic eye movement appear in Parkinson's disease, Alzheimer's disease and major depressive disorder patients, but difficulties for its applications arise from unclear processes of neuropathologicai development and individual differences in patients. Establishing nonhuman primates' model of mental disorders and monitoring saccadic parameters during the model construction will help us to overcome such difficulties,