CAJ | 학술논문

由壳聚糖(CS)、聚乙烯醇(PVA)和三聚磷酸钠(TPP)制备了壳聚糖/聚乙烯醇/三聚磷酸钠三元复合微球,探讨了体系中壳聚糖含量对复合微球的影响,以及离子种类及浓度和pH值对复合微球溶胀度的影响. 采用XRD、FTIR和SEM等测试技术对微球的组分、结构和形貌进行了表征. 结果表明,CS和PVA具有良好的相容性,随着CS含量的增加,PVA的结晶性逐渐降低,复合微球的粒径约为400～950 μm,表面较为粗糙;随着CS添加量的增加,凝胶平衡溶胀度先增大再减小,CS/PVA/TPP复合微球在pH值为3～8的溶胀度最大,且在同一种溶液中,随着离子浓度的增加,其溶胀度明显降低;复合微球具有溶胀-收缩可逆性,显示CS/PVA/TPP复合微球是pH/离子敏感型凝胶,可为药物缓释系统提供实验和理论依据.
유각취당(CS)、취을희순(PVA)화삼취린산납(TPP)제비료각취당/취을희순/삼취린산납삼원복합미구,탐토료체계중각취당함량대복합미구적영향,이급리자충류급농도화pH치대복합미구용창도적영향. 채용XRD、FTIR화SEM등측시기술대미구적조분、결구화형모진행료표정. 결과표명,CS화PVA구유량호적상용성,수착CS함량적증가,PVA적결정성축점강저,복합미구적립경약위400～950 μm,표면교위조조;수착CS첨가량적증가,응효평형용창도선증대재감소,CS/PVA/TPP복합미구재pH치위3～8적용창도최대,차재동일충용액중,수착리자농도적증가,기용창도명현강저;복합미구구유용창-수축가역성,현시CS/PVA/TPP복합미구시pH/리자민감형응효,가위약물완석계통제공실험화이론의거.
Chitosan/polyvinyl alcohol/sodium tripolyphosphate complex microparticles were prepared from chitosan(CS), polyvinyl alcohol(PVA) and sodium tripolyphosphate(TPP). The effects of CS content on complex microparticles and different ions, pH on the degree of equilibrium swelling were investigated. The component, structure and morphology of the complex microparticles were characterized by means of X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FTIR), scanning electron microscopy(SEM). The results indicate that the CS-PVA is a compatible system; the crystallization of PVA declines with the increase of CS content; the particle size is about 400～950 μm with rough surfaces. The equilibrium swelling tests show that with the increase of CS content, the equilibrium swelling ratio increases firstly then decreases. The CS/PVA/TPP complex microparticles show highest equilibrium swelling ratio in a pH 3～8 solution and tend to decrease with the increase of ion content in the same aqueous solution. The microparticles have swelling-shrinking reversibility, implying that CS/PVA/TPP complex microparticles are pH/ion-sensitive and could provide experimental and theoretical basis for drug delivery system.