CAJ | 학술논문

目的:综述国内外关于骨髓细胞输注诱导免疫耐受的研究概况.方法:应用计算机检索PubMed2000-01/2008-12期间的相关文章,检索词为"bonemarrowcells,transplantation immune tolerance",并限定文章语言种类为English.同时计算机检索中国生物医学文献数据库、中国期刊全文数据库2000-01/2008-12期间相关文章,检索词为"骨髓细胞,免疫耐受",并限定文章语言种类为中文.此外还手工查阅<器官移植学>、 <移植免疫耐受>,以及相关的中英文会议论文集.纳入标准:①形成免疫耐受的相关机制.②骨髓细胞输注诱导免疫耐受的方案.③骨髓细胞输入诱导免疫耐受的优、缺点.④同一领域选择近期发表或在权威杂志上发表的文章.排除标准:重复性研究或不切题文章.结果:免疫耐受的产生机制主要有清除、无能、调节或抑制、忽略等.骨髓细胞输注诱导免疫耐受的方案主要有骨髓细胞输注联合清髓性预处理、骨髓细胞输注联合非清髓性预处理、应用免疫抑制药物或化疗药物为主的预处理、以共刺激信号系统阻断为主的预处理、骨髓细胞联合间充质干细胞输注等.骨髓细胞输注诱导免疫耐受通过有效的免疫耐受机制可诱导形成持久稳定的特异免疫耐受,成为目前诱导移植耐受最为有效、最主要的方法.结论:到目前为止,临床免疫耐受仍然是不可控制的和偶发的.通过骨髓细胞输注诱导稳定的免疫耐受,必将为器官移植开辟新的天地.
목적:종술국내외관우골수세포수주유도면역내수적연구개황.방법:응용계산궤검색PubMed2000-01/2008-12기간적상관문장,검색사위"bonemarrowcells,transplantation immune tolerance",병한정문장어언충류위English.동시계산궤검색중국생물의학문헌수거고、중국기간전문수거고2000-01/2008-12기간상관문장,검색사위"골수세포,면역내수",병한정문장어언충류위중문.차외환수공사열<기관이식학>、 <이식면역내수>,이급상관적중영문회의논문집.납입표준:①형성면역내수적상관궤제.②골수세포수주유도면역내수적방안.③골수세포수입유도면역내수적우、결점.④동일영역선택근기발표혹재권위잡지상발표적문장.배제표준:중복성연구혹불절제문장.결과:면역내수적산생궤제주요유청제、무능、조절혹억제、홀략등.골수세포수주유도면역내수적방안주요유골수세포수주연합청수성예처리、골수세포수주연합비청수성예처리、응용면역억제약물혹화료약물위주적예처리、이공자격신호계통조단위주적예처리、골수세포연합간충질간세포수주등.골수세포수주유도면역내수통과유효적면역내수궤제가유도형성지구은정적특이면역내수,성위목전유도이식내수최위유효、최주요적방법.결론:도목전위지,림상면역내수잉연시불가공제적화우발적.통과골수세포수주유도은정적면역내수,필장위기관이식개벽신적천지.
OBJECTIVE: To summarize the study of bone marrow cell infusion-induced immune tolerance. METHODS: The Pubmed database was researched using the computer for articles published from January 2000 to December 2008 using the key words of "bone marrow cells, transplantation immune tolerance" in English. Simultaneously, Chinese Biomedical Literature Database and China Journal Full-text Database were retrieved for articles published from January 2000 to December 2008 using the key words of "bone marrow cells, immune tolerance" in Chinese. Besides, Organ Transplantation, Transplantation Immune Tolerance and Conference Proceedings of English and Chinese were retrieved by hand. Inclusion criteria: relevant mechanism of immune tolerance; scheme of bone marrow cell infusion-induced immune tolerance; advantages and disadvantages of bone marrow cell infusion-induced immune tolerance; articles in the same circle published in recent years or in authorized journals. Exclusion criteria: repetitive studies or irrelevant articles. RESULTS: Mechanism of immune tolerance comprised cleaning, inability, regulation or inhibition, and ignorance. The scheme of bone marrow cell infusion-induced immune tolerance mainly contained bone marrow cell infusion combined with myeloablative pretreatment, bone marrow cell infusion combined with non-myeloablative pretreatment, pretreatment with immunosuppressive drug or chemotherapeutics, pretreatment of costimulatory signaling blockage, bone marrow cell combined with mesenchymal stem cell infusion. Bone marrow cell infusion-induced immune toleranca could induce long-lasting stable specific immune tolerance by effective immune tolerance mechanism, and had been an effective main method for inducing transplanted tolerance. CONCLUSION: Up to now, clinical immune tolerance is still uncontrollable and facultative. Bone marrow cell infusion-induced stable immune tolerance can develop a new space for organ transplantation.