CAJ | 학술논문

探讨铅和乙醇联合作用对雄性大鼠生殖内分泌的影响。方法：雄性大白鼠54只，体重(207±17)g，采用2×3析因设计方法随机分为9组，每组6只，1次/d灌胃，5次/周，连续4周，染毒期满断头处死，取血做T、FSH、LH及血铅的分析。结果：染毒组与对照组比较，T值降低，FSH、LH、血铅增高(P<0.01)，联合染毒组与各单独染毒组(除B组T值)比较差异有显著性(P<0.01、P<0.05)；铅、乙醇及二者联合分别对3项内分泌指标及血铅的影响有显著性意义(P<0.01、P<0.05)；逐步回归显示血铅与FSH、LH呈正相关关系，与T呈负相关。结论：铅和乙醇联合作用对雄性大鼠生殖内分泌激素T、FSH和LH水平变化有明显的增毒作用。
탐토연화을순연합작용대웅성대서생식내분비적영향。방법：웅성대백서54지，체중(207±17)g，채용2×3석인설계방법수궤분위9조，매조6지，1차/d관위，5차/주，련속4주，염독기만단두처사，취혈주T、FSH、LH급혈연적분석。결과：염독조여대조조비교，T치강저，FSH、LH、혈연증고(P<0.01)，연합염독조여각단독염독조(제B조T치)비교차이유현저성(P<0.01、P<0.05)；연、을순급이자연합분별대3항내분비지표급혈연적영향유현저성의의(P<0.01、P<0.05)；축보회귀현시혈연여FSH、LH정정상관관계，여T정부상관。결론：연화을순연합작용대웅성대서생식내분비격소T、FSH화LH수평변화유명현적증독작용。
To investigate the combined effects of lead and ethanol on male reproductive endocrine of rats. Methods: Fifty four Wistar rats were divided into 9 groups randomly. One group was given with steamed water as control, and the other groups were administrated respectively with lead and/or ethanol at differ ent concentrations by ip for four weeks. At the end of fourth week after dministration, the male rats were sacri ficed. The analyses of FSH, LH, T and lead was undertaken. Results: Compared with control rats , the level of FSH, LH and lead were higher, but T was lower(P<0.01). Especially in all the combined experimental groups, FSH as well as LH and lead was significantly higher; whereas except B group, T was significantly lower than those of the lead or ethanol alone one(P<0.01 or P<0.05). ANOVA analysis indicted that lead and ethanol have interaction on the above indices(P<0.05 or P<0.01). The multiplr linear regression showed that there was positive linear correlation between blood lead and FSH or LH and negative linear corelation between blood lead and T. Conclusion:There were notable combined effects of lead and ethanol on the level of reproductive en docrine hormone in male rats.