CAJ | 학술논문

目的：探讨高血压(EH)患者胰岛素敏感性与其他代谢异常的关系及拉西地平干预作用的影响。方法：测定45例EH患者、20例正常人的胰岛素敏感指数(ISI)以及EH患者拉西地平治疗后的变化。结果：(1)EH+DSI(ISI↓)组(Ⅰ组，24例)血总胆固醇、甘油三酯、尿酸水平，BMI均比EH+NSI(正常ISI)组(Ⅱ组，21例)显著升高(P<0.05～0.001)，拉西地平治疗后ISI明显升高(P<0.05)；；(2)Ⅱ组的上述指标与对照组无明显差异，治疗后亦无明显改变。结论：ISI降低加重了EH患者的其他代谢紊乱，拉西地平可改善ISI的异常。
목적：탐토고혈압(EH)환자이도소민감성여기타대사이상적관계급랍서지평 간예작용적영향。 방법：측정45례EH환자、20례정상인적이도소민감지수(ISI)이급EH환자랍서지평치료 후적변화。 결과：(1)EH+DSI(ISI↓)조(Ⅰ조，24례)혈총담고순、감유삼지、뇨산수평，BMI균비EH+NSI(정상ISI)조(Ⅱ조，21례)현저승고(P<0.05～0.001)，랍서지평치료후ISI명현승고(P<0.05)；；(2)Ⅱ조적상술지표여대조조무명현차이，치료후역무명현개변。 결론：ISI강저가중료EH환자적기타대사문란，랍서지평가개선ISI적이상。
Objective:To investigate the relationship among insulin sens itivity index(ISI) and plasma lipid、uric acid(Ur),body mass index(BMI) in hypertensive patients(EH) and effects of lacidipine on metabolic abnormality .Methods: ISI was measured in 20 normal subjects (NS) and 45 EH patients before and after 4 weeks of lacidipine treatme nt (4～6mg/d,4 weeks).Results:(1)Total cholesterol,triglycerides(TG),Ur and BMI levels in EH+DSI(ISI↓) group(Ⅰ group,n=24) were significantly higher than those in EH+NSI(normal ISI) group (Ⅱ group,n=21) (P<0.05～0.001),after lacidipine therapy ISI significantly increased(P<0.05),TG significantly decreased(P<0.05);(2)Index as above stated in Ⅱ group was no obvious difference,compared with normal contro ls,aft er therapy also no obvious difference.Conclusion:ISI↓ may aggravate abnormality of plasm lipid and Ur metabolic in patients with EH.Lacidipine can improve ISI and decrease TG level in EH patients with ISI decrease.