CAJ | 학술논문

以往研究表明,儿茶酚胺系统可能参于注意缺损多动障碍(attention-deficit hyperactivityity disorder,ADHD)的发生,而儿茶酚胺-O-甲基转移酶(catechel-o-methyltransferase,COMT)是一种降解多巴胺和去甲肾上腺素系统的儿茶酚胺神经递质的酶.因此,采用两种以家系为基础的分析方法,即传递不平衡实验(transmissiondisequilibrium test,TDT)和单倍型为基础的单倍型相对风险率(haplotype-based haplotype relative risk,HHRR)去探讨COMT和中国人群中79个ADHD核心家系的关联性,ADHD诊断符合DSM-Ⅳ的诊断标准.TDT(x2=1.03,df=1,P＞0.05)和HHRR(x2=1.08,df=1,P＞0.05)两种方法的分析结果表明,COMT等位基因不能优先传递给ADHD儿童,提示在中国人群中ADHD与COMT基因无关联性.
이왕연구표명,인다분알계통가능삼우주의결손다동장애(attention-deficit hyperactivityity disorder,ADHD)적발생,이인다분알-O-갑기전이매(catechel-o-methyltransferase,COMT)시일충강해다파알화거갑신상선소계통적인다분알신경체질적매.인차,채용량충이가계위기출적분석방법,즉전체불평형실험(transmissiondisequilibrium test,TDT)화단배형위기출적단배형상대풍험솔(haplotype-based haplotype relative risk,HHRR)거탐토COMT화중국인군중79개ADHD핵심가계적관련성,ADHD진단부합DSM-Ⅳ적진단표준.TDT(x2=1.03,df=1,P＞0.05)화HHRR(x2=1.08,df=1,P＞0.05)량충방법적분석결과표명,COMT등위기인불능우선전체급ADHD인동,제시재중국인군중ADHD여COMT기인무관련성.
Previous studies suggested that the catecholaminergic systems may be involved in the pathogenesis of attention-deficit hyperactivity disorder(ADHD). Since catechei-o-methyltransferase(COMT) is an enzyme involved in the degradation of catecholaminergic neurotransmitters of the dopaminergic and noradrenergic systems,it is possible that COMT may play a role in ADHD. To test this hypothesis,we used two family-based analyses,the transmission disequilibrium test (TDT) and the haplotype-based haplotype relative risk (HHRR), to examine the possible association between COMT gene and DSM-Ⅳ-diagnosed ADHD in a Chinese sample consisting of 79 ADHD probands and their parents. Both TDT (x2 =1.03,df=1 ,P＞0.05) and HHRR (x2 =1.08,df= 1, P ＞0.05) analyses failed to detect preferential transmission of a COMT allele to the ADHD children. Our data suggested that there was no association between ADHD and the COMT gene in the Chinese population.