CAJ | 학술논문

学术背景:组织工程学的发展为组织或器官的修复与再建提供了可能,组织工程及高分子材料的研究进展值得探讨.目的:从生物相容性的角度出发论述了组织工程的研究内容及高分子组织工程材料在组织工程中的应用.检索策略:由该论文的研究人员应用计算机检索Pubmed数据库1990-01/2007-12相关文献,检索词"tissue engineering,tissue engineering materials,Polymers materials,bio-compatibility,bio-compatibility materials,cell-compatibility,cell-compatibility materials",并限定文章语言种类为English,同时计算机检索万方数据库1990-01/2007-12期间的相关文章,检索词为"组织工程;组织工程材料;高分子材料;生物相容性材料;生物相容性;细胞相容性;组织相容性",并限定文章语言种类为中文.共收集到81篇相关文献,对资料进行初审.纳入标准:文章内容应与生物相容性组织工程材料相关.排除标准:重复研究或Meta分析类文章.30篇文献符合纳入标准,排除的51篇文献为内容陈旧或重复.符合纳入标准的30篇文献中,19篇涉及生物相容性,11篇涉及细胞相容性材料.文献评价:文献的来源主要是Pubmed数据库及万方数据库.共得到论著类文章25篇,综述类文章5篇.资料综合:组织工程研究的内容包括种子细胞种植、生物材料植入及细胞移植.细胞的研究包括基因重组技术,将同种、自体或异种的组织体外分解成细胞后培养、增殖后进行构建.材料的研究主要集中于如何将材料与活细胞建成组织工程构建,即具有生物功能的活性材料,由于组织工程材料应具备最佳的材料与细胞界面反应效果,因此设计具有化学分子水平、三维分子水平的细胞/材料杂化界面,具有宏观三维分子水平、符合生物力学要求的装置是组织工程材料研究的核心.高分子材料由于具有良好的物理机械性能、分子结构更接近于生物体而广泛用作生物材料,并在组织工程领域发挥着重要作用.结论:研究开发具有良好组织相容性的材料是组织工程发展的基石,高分子材料具有较好的性能及接近于生物体的分子结构在组织工程中应用广泛. 學術揹景:組織工程學的髮展為組織或器官的脩複與再建提供瞭可能,組織工程及高分子材料的研究進展值得探討.目的:從生物相容性的角度齣髮論述瞭組織工程的研究內容及高分子組織工程材料在組織工程中的應用.檢索策略:由該論文的研究人員應用計算機檢索Pubmed數據庫1990-01/2007-12相關文獻,檢索詞"tissue engineering,tissue engineering materials,Polymers materials,bio-compatibility,bio-compatibility materials,cell-compatibility,cell-compatibility materials",併限定文章語言種類為English,同時計算機檢索萬方數據庫1990-01/2007-12期間的相關文章,檢索詞為"組織工程;組織工程材料;高分子材料;生物相容性材料;生物相容性;細胞相容性;組織相容性",併限定文章語言種類為中文.共收集到81篇相關文獻,對資料進行初審.納入標準:文章內容應與生物相容性組織工程材料相關.排除標準:重複研究或Meta分析類文章.30篇文獻符閤納入標準,排除的51篇文獻為內容陳舊或重複.符閤納入標準的30篇文獻中,19篇涉及生物相容性,11篇涉及細胞相容性材料.文獻評價:文獻的來源主要是Pubmed數據庫及萬方數據庫.共得到論著類文章25篇,綜述類文章5篇.資料綜閤:組織工程研究的內容包括種子細胞種植、生物材料植入及細胞移植.細胞的研究包括基因重組技術,將同種、自體或異種的組織體外分解成細胞後培養、增殖後進行構建.材料的研究主要集中于如何將材料與活細胞建成組織工程構建,即具有生物功能的活性材料,由于組織工程材料應具備最佳的材料與細胞界麵反應效果,因此設計具有化學分子水平、三維分子水平的細胞/材料雜化界麵,具有宏觀三維分子水平、符閤生物力學要求的裝置是組織工程材料研究的覈心.高分子材料由于具有良好的物理機械性能、分子結構更接近于生物體而廣汎用作生物材料,併在組織工程領域髮揮著重要作用.結論:研究開髮具有良好組織相容性的材料是組織工程髮展的基石,高分子材料具有較好的性能及接近于生物體的分子結構在組織工程中應用廣汎.
학술배경:조직공정학적발전위조직혹기관적수복여재건제공료가능,조직공정급고분자재료적연구진전치득탐토.목적:종생물상용성적각도출발논술료조직공정적연구내용급고분자조직공정재료재조직공정중적응용.검색책략:유해논문적연구인원응용계산궤검색Pubmed수거고1990-01/2007-12상관문헌,검색사"tissue engineering,tissue engineering materials,Polymers materials,bio-compatibility,bio-compatibility materials,cell-compatibility,cell-compatibility materials",병한정문장어언충류위English,동시계산궤검색만방수거고1990-01/2007-12기간적상관문장,검색사위"조직공정;조직공정재료;고분자재료;생물상용성재료;생물상용성;세포상용성;조직상용성",병한정문장어언충류위중문.공수집도81편상관문헌,대자료진행초심.납입표준:문장내용응여생물상용성조직공정재료상관.배제표준:중복연구혹Meta분석류문장.30편문헌부합납입표준,배제적51편문헌위내용진구혹중복.부합납입표준적30편문헌중,19편섭급생물상용성,11편섭급세포상용성재료.문헌평개:문헌적래원주요시Pubmed수거고급만방수거고.공득도론저류문장25편,종술류문장5편.자료종합:조직공정연구적내용포괄충자세포충식、생물재료식입급세포이식.세포적연구포괄기인중조기술,장동충、자체혹이충적조직체외분해성세포후배양、증식후진행구건.재료적연구주요집중우여하장재료여활세포건성조직공정구건,즉구유생물공능적활성재료,유우조직공정재료응구비최가적재료여세포계면반응효과,인차설계구유화학분자수평、삼유분자수평적세포/재료잡화계면,구유굉관삼유분자수평、부합생물역학요구적장치시조직공정재료연구적핵심.고분자재료유우구유량호적물리궤계성능、분자결구경접근우생물체이엄범용작생물재료,병재조직공정영역발휘착중요작용.결론:연구개발구유량호조직상용성적재료시조직공정발전적기석,고분자재료구유교호적성능급접근우생물체적분자결구재조직공정중응용엄범.
BACKGROUND: The development of tissue engineering has provided a possibility for repairing and reconstructing tissues or organs. However, studies on biomedical tissue-engineered and polymer tissue-engineered materials need to be investigated. OBJECTIVE: To clarify the content of tissue engineering and the application of polymer material in tissue engineering from the point of biocompatibility. RETRIEVAL STRATEGY: Using the terms "tissue engineering, tissue engineering materials, Polymers materials, bio-compatibility, bio-compatibility materials, cell-compatibility, cell-compatibility materials", we retrieved PubMed database to identify studies published between January 1990 and December 2007 in the English language. At the same time, we searched Wanfang database with the same terms in the Chinese language. After primarily selected, 81literatures were kept. Inclusive criteria: studies, whose contents are related to biocompatibility of tissue-engineered materials. Exclusive criteria: repetitive studies or Meta analysis. Thirty literatures corresponded to the inclusive criteria, and fifty-one were rejected due to obsolete or repetitive contents. Among the 30 included literatures, 19 were about biocompatibility, and the remaining 11 about cellular compatibility materials. LITERATURE EVALUATION: The included studies were mainly from Pubmed database and Wanfang database. A total of 25 treatises and 5 reviews were kept. DATA SYNTHESIS: The content of tissue engineering consisted of seeded cell inoculation, biomaterial implanting and cell transplantation. Allogenic, autogenous, and xenogenous tissues were in vitro broken into cells, and then reconstructed through inoculation and proliferation by gene reconstruction technique. Much attention should be focused on how to reconstruct tissue-engineered materials with materials and living cells, I.e. To reconstruct active materials with biological functions. Tissue-engineered materials should have the best interface reaction effect between material surface and cells. Therefore, the core of studying tissue-engineered materials is to design a device, which has chemical molecular level and three-dimensional molecular level cell/material mixed surface, and also has a three-dimensional molecular level appearance corresponding to biomechanical requirement. Polymer materials have good physical mechanical functions, and their molecular structures are closer to living body. Therefore, polymer materials are widely used as biomaterials and exert an important role in the field of tissue engineering. CONCLUSION:To study biomaterials with good tissue compatibility is the basis for tissue engineering development. Polymer materials are widely used in the tissue engineering due to their good property and molecular structure closer to living body.