CAJ | 학술논문

天然反义转录(NATs)是一组编码蛋白质或非编码蛋白质的RNAs,与其他(有义)转录物具有互补序列,可以调节有义链的表达.这种调节可以发生在转录水平或转录后水平,调节方式有转录干扰、RNA封闭、双链依赖机制或染色质重建(修饰)等.正义链和反义链分别加工成小RNAs调节基因表达,也是NATs调节基因表达的重要方式,如piRNAs的"乒乓机制".实验或计算机研究已经证明了NATs在生物中广泛存在,是一种重要的基因表达调节方式.文章论述了NATs的重要作用和机理,重点论述了NATs的调节机制和相关的小RNAs.
천연반의전록(NATs)시일조편마단백질혹비편마단백질적RNAs,여기타(유의)전록물구유호보서렬,가이조절유의련적표체.저충조절가이발생재전록수평혹전록후수평,조절방식유전록간우、RNA봉폐、쌍련의뢰궤제혹염색질중건(수식)등.정의련화반의련분별가공성소RNAs조절기인표체,야시NATs조절기인표체적중요방식,여piRNAs적"핑퐁궤제".실험혹계산궤연구이경증명료NATs재생물중엄범존재,시일충중요적기인표체조절방식.문장논술료NATs적중요작용화궤리,중점논술료NATs적조절궤제화상관적소RNAs.
Natural antisense transcripts(NATs)are coding or non-coding RNAs with sequence complementarity to other transcripts(sense transcripts).These RNAs could potentially regulate the expression of their sense parmer(s)at either the transcriptional or post-transcriptional level through a variety of biological mechanisms,such as transcription interference,RNA masking,dsRNA-dependent mechanisms,and chromatin remodelling(modification).We speculated that both of sense and antisense transcripts may be sliced to form small RNAs,which is also an important mechanism for NATs to regulate gene expression,such as rasiRNAs in"ping-pong".Experimental and computational analyses have demonstrated the widespread occurrence of NATs in a wide range of species.Here,we reviewed the current understanding of NATs function and its mechanistic basis.We hypothesized that the regulation of antisense transcription and small RNAs were derived from NATs.