CAJ | 학술논문

目的探讨影响抗结核药物性肝损伤的危险因素,并提出护理对策.方法收集2003年1月至2009年1月住院进行标准规范化抗结核药物治疗的1079例患者资料,对可能产生抗结核药物性肝损伤的危险因素进行逻辑回归分析.结果抗结核药物性肝损伤的发生率为14.0%,回归分析显示,既往肝病史、心血管疾病、蛋白质营养不良、乙肝表面抗原(HBs-Ag)阳性及嗜酒患者是发生药物性肝损伤的主要危险因素.结论对上述的危险因素应尽早采取护理干预和治疗,以减少药物性肝损伤的发生.
목적 탐토영향항결핵약물성간손상적위험인소,병제출호리대책.방법 수집2003년1월지2009년1월주원진행표준규범화항결핵약물치료적1079례환자자료,대가능산생항결핵약물성간손상적위험인소진행라집회귀분석.결과 항결핵약물성간손상적발생솔위14.0%,회귀분석현시,기왕간병사、심혈관질병、단백질영양불량、을간표면항원(HBs-Ag)양성급기주환자시발생약물성간손상적주요위험인소.결론 대상술적위험인소응진조채취호리간예화치료,이감소약물성간손상적발생.
Objective To study the risk factors of anti-tuberculosis drug-induced liver disease and its nursing care. Methods 1079 TB patients at Guhua Hospital from January 2003 to January 2009 were studied.Risk factors which caused drug-induced liver disease were analyzed by logistic regression. Results 14.0% of the observed patients had anti-tuberculosis drug-induced liver disease. The logistic regression analysis shows that the following four factors were the causes of anti-tuberculosis drug-induced liver disease: hepatitis history;chronic cardiovascular disease; protein-malnutrition; H Bs-Ag ( + ) and drunkard men. Conclusions Take nursing care and preventive measures as early as possible to reduce the possibility of anti-tuberculosis druginduced liver disease.