CAJ | 학술논문

观察低出生体重大鼠不同发育时期骨骼肌形态结构的变化和胰岛素抵抗情况.采用孕期低蛋白饮食法建立低出生体重仔鼠模型.于出生后7 d、21 d、2月龄测定仔鼠空腹血糖、血清胰岛素值,并检测骨骼肌形态结构.自7 d至2月龄,低出生体重仔鼠骨骼肌纤维均有明显萎缩、排列稀疏紊乱;2月龄时超微结构明显异常.2月龄内低出生体重仔鼠血糖和血清胰岛素与对照组比较无差异.
관찰저출생체중대서불동발육시기골격기형태결구적변화화이도소저항정황.채용잉기저단백음식법건립저출생체중자서모형.우출생후7 d、21 d、2월령측정자서공복혈당、혈청이도소치,병검측골격기형태결구.자7 d지2월령,저출생체중자서골격기섬유균유명현위축、배렬희소문란;2월령시초미결구명현이상.2월령내저출생체중자서혈당화혈청이도소여대조조비교무차이.
To study the changes in skeletal muscle structure and insulin resistance of low birth weight rats.The low birth weight filial rat model was established by feeding low protein diet to the pregnant rat during gestation.At 7 d,21 d,and 2 months,blood glucose and serum insulin were measured,and the structure of skeletal muscle was observed.From 7 d to 2 months,the muscle fibers of low birth weight rat were atrophic and arranged in disorder.The ultrastructure of skeletal muscle was also abnormal distinctly at 2 months.No differences of blood glucose and rerum insulin were found between the two groups.