国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2012年
4期
303-305
,共3页
热孜万古丽·吾买尔%斯拉甫·艾白%艾克拜尔·安扎尔%阿依努尔·艾买提
熱孜萬古麗·吾買爾%斯拉甫·艾白%艾剋拜爾·安扎爾%阿依努爾·艾買提
열자만고려·오매이%사랍보·애백%애극배이·안찰이%아의노이·애매제
银屑病%细胞因子%维吾尔医综合疗法
銀屑病%細胞因子%維吾爾醫綜閤療法
은설병%세포인자%유오이의종합요법
Psoriasis%Cytokine%Uygur medicine
目的 探讨维吾尔医(简称“维医”)综合疗法对细胞因子免疫调节机制的影响.方法 采用酶联免疫吸附试验(ELISA)测定80例寻常型银屑病患者维医综合治疗前后血清中干扰素(IFN-γ)、白细胞介素2 (IL-2)、肿瘤坏死因子(TNF-α)及白细胞介素10(IL-10)、白细胞介素4(IL-4),并与60例健康成人进行对照.结果 ①患者组治疗前血清IFN-γ、IL-2、TNF-α水平高于对照组,其中IFN-γ、IL-2与对照组比较,差异有统计学意义(PIFN-γ=0.043,PIL-2=0.008); IL-10、IL-4水平低于对照组(PIL-10=0.041,PIL-4=0.049).②治疗后,患者组IFN-γ、TNF-α、IL-10、IL-4与对照组比较,差异无统计学意义(PIFN-γ=0.803,PTNF-α=0.190,PIL-10=0.146,PIL-4=0.920),但IL-2高于对照组.结论 维医综合治疗可改善Th1及Th2细胞分泌的细胞因子失衡.
目的 探討維吾爾醫(簡稱“維醫”)綜閤療法對細胞因子免疫調節機製的影響.方法 採用酶聯免疫吸附試驗(ELISA)測定80例尋常型銀屑病患者維醫綜閤治療前後血清中榦擾素(IFN-γ)、白細胞介素2 (IL-2)、腫瘤壞死因子(TNF-α)及白細胞介素10(IL-10)、白細胞介素4(IL-4),併與60例健康成人進行對照.結果 ①患者組治療前血清IFN-γ、IL-2、TNF-α水平高于對照組,其中IFN-γ、IL-2與對照組比較,差異有統計學意義(PIFN-γ=0.043,PIL-2=0.008); IL-10、IL-4水平低于對照組(PIL-10=0.041,PIL-4=0.049).②治療後,患者組IFN-γ、TNF-α、IL-10、IL-4與對照組比較,差異無統計學意義(PIFN-γ=0.803,PTNF-α=0.190,PIL-10=0.146,PIL-4=0.920),但IL-2高于對照組.結論 維醫綜閤治療可改善Th1及Th2細胞分泌的細胞因子失衡.
목적 탐토유오이의(간칭“유의”)종합요법대세포인자면역조절궤제적영향.방법 채용매련면역흡부시험(ELISA)측정80례심상형은설병환자유의종합치료전후혈청중간우소(IFN-γ)、백세포개소2 (IL-2)、종류배사인자(TNF-α)급백세포개소10(IL-10)、백세포개소4(IL-4),병여60례건강성인진행대조.결과 ①환자조치료전혈청IFN-γ、IL-2、TNF-α수평고우대조조,기중IFN-γ、IL-2여대조조비교,차이유통계학의의(PIFN-γ=0.043,PIL-2=0.008); IL-10、IL-4수평저우대조조(PIL-10=0.041,PIL-4=0.049).②치료후,환자조IFN-γ、TNF-α、IL-10、IL-4여대조조비교,차이무통계학의의(PIFN-γ=0.803,PTNF-α=0.190,PIL-10=0.146,PIL-4=0.920),단IL-2고우대조조.결론 유의종합치료가개선Th1급Th2세포분비적세포인자실형.
Objective To observe the changes of representative cytokine of Th1 and Th2 cells in ordinary psoriasis patient's serum before and after the treatment of uygur medicine and to explore its possible mechanism in the oceurance of psoriasis.Methods Five cytokine including IFN-γ,IL-2.TNF-α,IL-10,IL-4 in peripheral blood serum of 80 ordinary psoriasis padent were assayed by enzyme linked immunosorbent assay (ELISA) before and after combined modality therapy of Uygur-medicine.60 healthy volunteers were recurited for making a contrast.Results ① before treatment,contrast to the healthy volunteer's,the IFN-γ,IL-2 and TNF-α levels of ordinary psoriasis patients were higher,in which,IFN-γ and IL-2 had statistical significance(P＜0.001 ).While IL-10 and IL-4 were significantly lower than the healthy contrasts(PIL-10=0.041,PIL-4=0.049) ; ② after the therapy,IFN-γ,IL-2,TNF-α,IL-10 and IL-4 levels of ordinary psoriasis patients had no significant difference comparing to the healthy volunteer's (PIFN-γ=0.803,PTNF-α=0.190,PIL-10=0.146,PIL-4=0.920),but IL-2 level was significantly higher.Conclusion Unbalance of peripheral blood CD4+T cell subgroup (Th1/Th2) differentiation and their secretion cytokines are correlated to the initiation and development of ordinary psoriasis.Uygur-medicine combined modality therapy can significantly improve the unbalance status of cytokines secreted by Th1 and Th2 cells.
