CAJ | 학술논문

目的了解热休克蛋白27(HSP27)在食管鳞癌、癌旁组织和切缘正常食管黏膜中的表达,分析其表达差异,并探讨其与食管癌发生发展的关系.方法应用免疫组化Envision二步法,观察HSP27在食管鳞癌、癌旁组织和切缘正常食管黏膜中的表达,并比较其间是否存在差异.结果食管鳞癌、癌旁组织和切缘正常食管黏膜中HSP27的阳性表达率分别为73.3％、53.5％和25.3％；HSP27在食管鳞癌中的阳性表达率高于在癌旁组织(P＜0.05),在癌旁组织中的阳性表达率高于在切缘正常食管黏膜(P ＜0.001).随着食管鳞癌高、中、低分化程度的不同,HSP27的阳性表达率逐渐降低,但差异无统计学意义(P＞0.05).结论 HSP27可能与食管鳞癌的发生发展有关.
목적 료해열휴극단백27(HSP27)재식관린암、암방조직화절연정상식관점막중적표체,분석기표체차이,병탐토기여식관암발생발전적관계.방법 응용면역조화Envision이보법,관찰HSP27재식관린암、암방조직화절연정상식관점막중적표체,병비교기간시부존재차이.결과 식관린암、암방조직화절연정상식관점막중HSP27적양성표체솔분별위73.3％、53.5％화25.3％；HSP27재식관린암중적양성표체솔고우재암방조직(P＜0.05),재암방조직중적양성표체솔고우재절연정상식관점막(P ＜0.001).수착식관린암고、중、저분화정도적불동,HSP27적양성표체솔축점강저,단차이무통계학의의(P＞0.05).결론 HSP27가능여식관린암적발생발전유관.
Objective To investigate the expression of heat shock protein 27(HSP27)in esophageal squamous carcinoma,mucosa adjacent to carcinoma and normal esophageal mucosa,and its relationship with the carcinogenesis of esophageal carcinoma.Methods The expression of HSP27 was observed in 86 specimens from esophageal squamous carcinoma,86 from mucosa adjacent to carcinoma and 75 from normal esophageal mucosa by immunohistochemistry.Results The expression of HSP27 in esophageal squamous carcinomas was higher than those in mucosa adjacent to carcinoma(P ＜ 0.05);the expression of HSP27 in mucosa adjacent to carcinoma was higher than those in normal esophageal mucosa(P ＜0.001).There was no significant difference in the expression of HSP27 in esophageal squamous carcinomas with different differentiation degree(P ＞ 0.05).Conclusion Expression of HSP27 was associated with the carcinogenesis of esophageal squamous carcinoma.