CAJ | 학술논문

对82例中枢性性早熟(CPP)女童使用促性腺激素释放激素类似物(GnRHa)治疗后线性生长及终身高进行评价.治疗两年以上患者的第2年生长速度与其治疗第2年和第1年的骨龄差值呈正相关(P<0.01).治疗后按骨龄的身高标准差分值增大,预测成人身高提高.随访26例达终身高患者,平均靶身高高于遗传靶身高.故适量的GnRHa治疗辅以有氧运动能够有效地改善CPP女童生长速度及终身高.
대82례중추성성조숙(CPP)녀동사용촉성선격소석방격소유사물(GnRHa)치료후선성생장급종신고진행평개.치료량년이상환자적제2년생장속도여기치료제2년화제1년적골령차치정정상관(P<0.01).치료후안골령적신고표준차분치증대,예측성인신고제고.수방26례체종신고환자,평균파신고고우유전파신고.고괄량적GnRHa치료보이유양운동능구유효지개선CPP녀동생장속도급종신고.
The effect of gonadotropin-releasing hormone analogue(GnRHa) on lineafity growth and final height in 82 girls with central precocious puberty (CPP) was evaluated. The growth velocity in the second year was positively correlated with the difference value of bone age between the first year and the second year after treatment. The height standard deviation score for bone age and predicted aduh height increased after treatment. Twenty-six girls who had been followed to final height obtained better adult height than target height. GnRHa in combination with aerobic exercise increases linear growth and final height in girls with CPP.