中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
11期
762-765
,共4页
薛满忠%李永杰%高旭光%张春芳
薛滿忠%李永傑%高旭光%張春芳
설만충%리영걸%고욱광%장춘방
脑梗死%动脉粥样硬化%颈动脉狭窄
腦梗死%動脈粥樣硬化%頸動脈狹窄
뇌경사%동맥죽양경화%경동맥협착
Cerebral infarction%Atherosclerosis%Carotid artery stenosis
目的 分析脑梗死患者颅内外动脉粥样硬化性狭窄的分布情况,探讨动脉粥样硬化危险因素与病变部位的关系.方法 搜集2008年7月至2010年6月间在北京大学人民医院神经内科住院的由经颅多普勒、颈动脉彩色超声、颅内磁共振血管成像和数字减影血管造影诊断存在颅内和(或)颅外动脉粥样硬化性狭窄的428例脑梗死患者资料,根据血管病变部位分组,比较各组间动脉粥样硬化危险因子的差别.结果 颅内动脉病变组199例(46.5%),颅外动脉病变组129例(30.1%),颅内合并颅外动脉病变组100例(23.4%);颅内动脉病变组总胆固醇(TC)、低密度脂蛋白胆固醇酯(LDL-C)水平高于其他两组(TC:P1=0.001,P2=0.000;LDL-C:P1=0.004,P2=0.039),颅内合并颅外动脉病变组男性比例高于颅内动脉病变组(P=0.003).结论 脑梗死患者颅内动脉粥样硬化性狭窄多于颅外,单纯颅内动脉狭窄组血脂控制欠佳,大多数传统的动脉粥样硬化危险因素并不是动脉狭窄发生部位的决定因子.
目的 分析腦梗死患者顱內外動脈粥樣硬化性狹窄的分佈情況,探討動脈粥樣硬化危險因素與病變部位的關繫.方法 搜集2008年7月至2010年6月間在北京大學人民醫院神經內科住院的由經顱多普勒、頸動脈綵色超聲、顱內磁共振血管成像和數字減影血管造影診斷存在顱內和(或)顱外動脈粥樣硬化性狹窄的428例腦梗死患者資料,根據血管病變部位分組,比較各組間動脈粥樣硬化危險因子的差彆.結果 顱內動脈病變組199例(46.5%),顱外動脈病變組129例(30.1%),顱內閤併顱外動脈病變組100例(23.4%);顱內動脈病變組總膽固醇(TC)、低密度脂蛋白膽固醇酯(LDL-C)水平高于其他兩組(TC:P1=0.001,P2=0.000;LDL-C:P1=0.004,P2=0.039),顱內閤併顱外動脈病變組男性比例高于顱內動脈病變組(P=0.003).結論 腦梗死患者顱內動脈粥樣硬化性狹窄多于顱外,單純顱內動脈狹窄組血脂控製欠佳,大多數傳統的動脈粥樣硬化危險因素併不是動脈狹窄髮生部位的決定因子.
목적 분석뇌경사환자로내외동맥죽양경화성협착적분포정황,탐토동맥죽양경화위험인소여병변부위적관계.방법 수집2008년7월지2010년6월간재북경대학인민의원신경내과주원적유경로다보륵、경동맥채색초성、로내자공진혈관성상화수자감영혈관조영진단존재로내화(혹)로외동맥죽양경화성협착적428례뇌경사환자자료,근거혈관병변부위분조,비교각조간동맥죽양경화위험인자적차별.결과 로내동맥병변조199례(46.5%),로외동맥병변조129례(30.1%),로내합병로외동맥병변조100례(23.4%);로내동맥병변조총담고순(TC)、저밀도지단백담고순지(LDL-C)수평고우기타량조(TC:P1=0.001,P2=0.000;LDL-C:P1=0.004,P2=0.039),로내합병로외동맥병변조남성비례고우로내동맥병변조(P=0.003).결론 뇌경사환자로내동맥죽양경화성협착다우로외,단순로내동맥협착조혈지공제흠가,대다수전통적동맥죽양경화위험인소병불시동맥협착발생부위적결정인자.
Objective To investigate the distribution of atherosclerotic stenosis of cerebral arteries in Chinese patients suffered from cerebral infarction,and to determine if there are any factors correlating with intracranial and extracranial atherosclerosis.Methods For this study,we enrolled 428 consecutive inpatients with cerebral infarction,All patients were examined with transcranial Doppler ultrasonography (TCD) and carotid duplex ultrasound to detect atherosclerotic lesions in intracranial and extracranial cerebral arteries,some also were examined by magnetic resonance angiography (MRA) and/or digital subtraction angiography(DSA),they were all diagnosed as atherosclerotic cerebral artery stenosis.The patients were divided into three groups according to the different location of lesions,the frequency of risk factors of atherosclerosis and the demographic parameters were compared among these groups.Results 199 cases (46.5%) had only intracranial artery stenosis,129 cases (30.1%) had only extracranial artery stenosis,100 cases (23.4%) had both intracranial and extracranial stenosis (combine group).Compared with the other two groups,the levels of total cholesterol and low density lipoprotein-cholesterol of the intracranial artery group are both significantly higher(TC:P1 = 0.001,P2 = 0.000;LDL-C:P1 = 0.004,P2 = 0.039),the combine group had a significant higher ratio of male than that of the intracranial artery group (P =0.003),there were no any other atherosclerosis risk factors had association with the location of cerebral artery stenosis.Conclusion The occurrence of stenosis in intracranial arteries is more frequent than that in extracranil arteries in Chinese patients with cerebral infarction,and the lipid level is higher in the intracranial artery group,most risk factors of atherosclerosis may not be major determinants of location for cerebral atherosclerosis.
