CAJ | 학술논문

背景:目前还没有将淀粉,聚乙烯醇膜应用于引导组织再生技术的研究,实验结合天然高分子和合成高分子的优点制备成多孔结构的引导组织再生膜.目的:不同制备工艺条件对淀粉,聚乙烯醇膜性能的影响.方法:以聚乙烯醇和淀粉为主要原料,通过溶液浇注、冷冻干燥法制备具有多孔结构的引导组织再生膜,考察原料配比、溶液浓度和预冻温度对多孔薄膜性能的影响.对薄膜的表面形貌、孔隙率、吸水率、力学性能及细胞毒性进行了表征.结果与结论:不同工艺条件下制备膜的孔径在1～50 μm,孔隙率在60%～70%,拉伸强度在12～26 MPa,并且该膜具有良好的生物相容性和亲水性.当溶液浓度为5%,预冻温度为-30℃时该膜表面孔的分布比较均匀,淀粉含量越多,孔径越大.
배경:목전환몰유장정분,취을희순막응용우인도조직재생기술적연구,실험결합천연고분자화합성고분자적우점제비성다공결구적인도조직재생막.목적:불동제비공예조건대정분,취을희순막성능적영향.방법:이취을희순화정분위주요원료,통과용액요주、냉동간조법제비구유다공결구적인도조직재생막,고찰원료배비、용액농도화예동온도대다공박막성능적영향.대박막적표면형모、공극솔、흡수솔、역학성능급세포독성진행료표정.결과여결론:불동공예조건하제비막적공경재1～50 μm,공극솔재60%～70%,랍신강도재12～26 MPa,병차해막구유량호적생물상용성화친수성.당용액농도위5%,예동온도위-30℃시해막표면공적분포비교균균,정분함량월다,공경월대.
BACKGROUND: There is no study on starch/polyvinyl alcohol (PVA) as guided tissue regeneration membranes. The guided tissue regeneration membrane with porous structure were prepared, which combined with the advantages of natural polymer and synthetic polymer. OBJECTIVE: To research the effects of the preparation conditions on the properties of starch/PVA membranes. METHODS: The porous membranes of guiding tissue regeneration were prepared mainly by starch and PVA through solution mixing, casting, freezing and drying. The effects of the mass ratio of PVA and starch, solution concentration, and pre-freezing temperature on the properties of the membrane were researched. The surface morphology, tensile strength, porous ratio, water absorbance and cell cytotoxicity were characterized. RESULTS AND CONCLUSION: The aperture of the membrane was 1-50 μm, the porosity was 60%-70%, and the tensile strength was 12-26 MPa. And this membrane had the excellent biocompatibility and hydrophilicity. The pores in the surface were evenly distributed with the solution concentration of 5% and the pre-freezing temperature of -30℃. The more content of starch was, and the larger of the aperture was.