CAJ | 학술논문

支气管哮喘(简称哮喘)是一种免疫介导的气道反应性增高的炎症性疾病.病毒在哮喘的发作和加重过程中起着重要的作用,呼吸道合胞病毒(RSV)是成人及婴幼儿下呼吸道感染最常见的病原体之一.近年来研究显示,RSV感染是儿童哮喘发生的重要危险因素,并可引起成人哮喘喘息症状加重.RSV感染诱发喘息和哮喘发作的机制十分复杂,是由多因素相互作用的结果,感染后气道上皮细胞损伤、免疫功能失常、气道炎症以及气道神经调控失调等发挥重要的作用.
지기관효천(간칭효천)시일충면역개도적기도반응성증고적염증성질병.병독재효천적발작화가중과정중기착중요적작용,호흡도합포병독(RSV)시성인급영유인하호흡도감염최상견적병원체지일.근년래연구현시,RSV감염시인동효천발생적중요위험인소,병가인기성인효천천식증상가중.RSV감염유발천식화효천발작적궤제십분복잡,시유다인소상호작용적결과,감염후기도상피세포손상、면역공능실상、기도염증이급기도신경조공실조등발휘중요적작용.
Bronchial asthma (asthma) is an immune- mediated inflammatory disease with airway hyperresponsiveness which is a serious problem for human health.Virus bas be shown that it plays an important role in asthma attact and exacerbation.Respiratory syncytial virus (RSV) is one of the most common pathogens caused lower respiratory tract infection in infants and adults.Recently reports shown that RSV infection was an important risk factor caused asthma in infants,and lead to wheezing exacerbation in adult asthma.The mechanism of wheezing and asthma induced by RSV infection is complicated.It is a result by multiple factors interacted.and those play an important role such as airway epithelial cell damage,immune dysfunction,airway inflammation and regulation disorders of airway neural function after RSV infection.