中华超声影像学杂志
中華超聲影像學雜誌
중화초성영상학잡지
CHINESE JOURNAL OF ULTRASONOGRAPHY
2008年
4期
319-322
,共4页
张玮%李荔%康永军%李杰%李嫚%王爱光%曲素慧%张莉%刘好田%刘爱莲
張瑋%李荔%康永軍%李傑%李嫚%王愛光%麯素慧%張莉%劉好田%劉愛蓮
장위%리려%강영군%리걸%리만%왕애광%곡소혜%장리%류호전%류애련
超声检查%造影剂%癌,肝细胞%高强度聚焦超声
超聲檢查%造影劑%癌,肝細胞%高彊度聚焦超聲
초성검사%조영제%암,간세포%고강도취초초성
Ultrasonography%Contrast media%Carcinoma,hepatocellular%High intellsitv focused uhrasound
目的 探讨高强度聚焦超声(HIFU)治疗原发性肝癌即时超声造影评价并指导补充治疗的临床应用价值.方法 55例原发性肝细胞癌患者(68个病灶)随机分为A、B两组,其中A组30例(38个病灶)治疗前及治疗后10 min进行超声造影检查,并对未完全灭活的病灶针对性地行HIFU补充治疗;B组25例(30个病灶)为对照组.观察治疗的安全性及治疗后两组患者临床症状、甲胎蛋白、影像学等各项指标的变化,并比较两组患者的远期疗效.结果 HIFU治疗后即时超声造影发现A组19个病灶未完全灭活并补充治疗.全部患者均无严重并发症出现.治疗后A、B两组患者甲胎蛋白值下降率分别为86.7%(26/30)、64.0%(16/25);肿瘤完全坏死率分别为97.3%(37/38)、60.0%(18/30);半年、1年生存率分别为100%、90.0%和76.0%、68.0%;两组差异均具有统计学意义(P＜0.05).结论 HIFU治疗原发性肝癌即时超声造影评价并指导补充治疗有利于病灶的完全灭活,可以缓解症状,改善生活质量,延长生存期,具有较好的临床应用价值.
目的 探討高彊度聚焦超聲(HIFU)治療原髮性肝癌即時超聲造影評價併指導補充治療的臨床應用價值.方法 55例原髮性肝細胞癌患者(68箇病竈)隨機分為A、B兩組,其中A組30例(38箇病竈)治療前及治療後10 min進行超聲造影檢查,併對未完全滅活的病竈針對性地行HIFU補充治療;B組25例(30箇病竈)為對照組.觀察治療的安全性及治療後兩組患者臨床癥狀、甲胎蛋白、影像學等各項指標的變化,併比較兩組患者的遠期療效.結果 HIFU治療後即時超聲造影髮現A組19箇病竈未完全滅活併補充治療.全部患者均無嚴重併髮癥齣現.治療後A、B兩組患者甲胎蛋白值下降率分彆為86.7%(26/30)、64.0%(16/25);腫瘤完全壞死率分彆為97.3%(37/38)、60.0%(18/30);半年、1年生存率分彆為100%、90.0%和76.0%、68.0%;兩組差異均具有統計學意義(P＜0.05).結論 HIFU治療原髮性肝癌即時超聲造影評價併指導補充治療有利于病竈的完全滅活,可以緩解癥狀,改善生活質量,延長生存期,具有較好的臨床應用價值.
목적 탐토고강도취초초성(HIFU)치료원발성간암즉시초성조영평개병지도보충치료적림상응용개치.방법 55례원발성간세포암환자(68개병조)수궤분위A、B량조,기중A조30례(38개병조)치료전급치료후10 min진행초성조영검사,병대미완전멸활적병조침대성지행HIFU보충치료;B조25례(30개병조)위대조조.관찰치료적안전성급치료후량조환자림상증상、갑태단백、영상학등각항지표적변화,병비교량조환자적원기료효.결과 HIFU치료후즉시초성조영발현A조19개병조미완전멸활병보충치료.전부환자균무엄중병발증출현.치료후A、B량조환자갑태단백치하강솔분별위86.7%(26/30)、64.0%(16/25);종류완전배사솔분별위97.3%(37/38)、60.0%(18/30);반년、1년생존솔분별위100%、90.0%화76.0%、68.0%;량조차이균구유통계학의의(P＜0.05).결론 HIFU치료원발성간암즉시초성조영평개병지도보충치료유리우병조적완전멸활,가이완해증상,개선생활질량,연장생존기,구유교호적림상응용개치.
Objective To explore the value of clinical application of high intensity focused uitrasound (HIFU)supplementary treatment evaluated and instructed by immediate contrast-enhanced uitrasound for Drimary hepatic carcinoma.Methods Fifty-five cases(68 lesions)of hepatocellular carcinoma(HCC)were randomized into 2 groups,30 cases(38 lesions)in group A and 25 cases(30 lesions)in group B.Patients of group A were examined by contrast-enhanced ultrasound before and after therapy in 10 minutes.The lesions of incomplete deactivation were treated by HIFU in time.The treatment security and the therapeutic effects were observed by the clinical symptom,serum AFP and imaging appearance.The long-term therapeutic effects were judged by follow-up survival rate.Results Nineteen lesions in group A were found incomplete deactivation and run supplementary treatment in time.No serious complication was identified.The AFP descending rate was 86.7%(26/30)in group A,64.0%(16/25)in group B,respectively(P＜0.05),and the lesions complete necrosis rate was 97.3%(37/38),60.0%(1 8/30),respectively(P＜0.05).Half year survival rate was 100%in group A,90.0%ih grouD B(P＜0.05),and 1 year survival rate was 76.0%,68.0%,respectively(P＜0.05).Conclusions HIFU supplementary treatment evaluated and instructed by immediate contrast-enhanced ultrasound for primary hepatic carcinoma can help to destroy the lesions completely,alleviate the symptom,reduce recurrence,improve life quality,lengthen the lifcrime,and has the better clinical practice value.
