CAJ | 학술논문

目的探讨干燥综合征(SS)患者食管功能障碍的表现形式以及与吞咽困难、实验室检查及其他辅助检查的关系.方法采用定点牵拉法对31例SS患者及18名健康志愿者进行食管压力测定.结果 19例(61%)SS患者和4名(22%)健康对照出现上食管括约肌静息压减低,两组差异有统计学意义(p=0.008);15例(48%)SS患者存在食管体部蠕动异常,其中无效食管动力6例、"胡桃夹"食管动力3例以及非特异性食管蠕动异常6例.原发性SS与继发性SS患者食管体部各段蠕动波幅、时间和速度的差异无统计学意义.食管功能障碍与SS的临床表现、实验室检查及其他辅助检查无相关性.结论 SS可出现食管功能障碍,且呈现明显的多样性.
목적 탐토간조종합정(SS)환자식관공능장애적표현형식이급여탄인곤난、실험실검사급기타보조검사적관계.방법 채용정점견랍법대31례SS환자급18명건강지원자진행식관압력측정.결과 19례(61%)SS환자화4명(22%)건강대조출현상식관괄약기정식압감저,량조차이유통계학의의(p=0.008);15례(48%)SS환자존재식관체부연동이상,기중무효식관동력6례、"호도협"식관동력3례이급비특이성식관연동이상6례.원발성SS여계발성SS환자식관체부각단연동파폭、시간화속도적차이무통계학의의.식관공능장애여SS적림상표현、실험실검사급기타보조검사무상관성.결론 SS가출현식관공능장애,차정현명현적다양성.
Objective To investigate the manifestations of esophageal motility disorders and evaluate the association between them and dysphagia, laboratory tests and other accessory examinations in patients with Sj(o)gren's syndrome (SS). Methods Esophageal manometry was performed in 31 patients with SS and 18 healthy volunteers by the step pull-through method. Results Decreased upper esophageal sphincter pressure was detected in 19 of the 31 patients (61%) with SS, while 4 of 18 (22%) in controls. The frequency was significantly higher in patients than in healthy controls (P=0.008). Fifteen of 31 patients (48%) showed various patterns of esophageal dysfunction including ineffective esophageal motility in 6 patients, nutcracker esophagus in 3 patients and nonspecific dysmotility in 6 patients. No major differences were found in esophageal parameters (peak amplitude, wave duration and velocity) when comparing primary SS with secondary SS. These esophageal abnormalities were not correlated with clinical manifestations, laboratory examinations and other auxiliary examinations. Conclusion Patients with SS may have esophageal motility disorders, which can presents with different patterns.