国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2012年
3期
284-287
,共4页
血管内皮生长因子%肾小管间质损伤%信号传导
血管內皮生長因子%腎小管間質損傷%信號傳導
혈관내피생장인자%신소관간질손상%신호전도
Vascular endothelial growth factors%Tubulointerstitial injury%Signal transduction
血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)能促进内皮细胞的分化、增殖、迁移,并增强血管通透性,参与微血管病变的病理过程.近年研究发现,VEGF与肾小管间质病变有关,其参与肾间质细胞外基质的合成与降解.因此,VEGF在肾小管损伤中的重要作用逐渐被重视.该文就VEGF与肾小管间质损伤的研究进展作一综述.
血管內皮細胞生長因子(vascular endothelial growth factor,VEGF)能促進內皮細胞的分化、增殖、遷移,併增彊血管通透性,參與微血管病變的病理過程.近年研究髮現,VEGF與腎小管間質病變有關,其參與腎間質細胞外基質的閤成與降解.因此,VEGF在腎小管損傷中的重要作用逐漸被重視.該文就VEGF與腎小管間質損傷的研究進展作一綜述.
혈관내피세포생장인자(vascular endothelial growth factor,VEGF)능촉진내피세포적분화、증식、천이,병증강혈관통투성,삼여미혈관병변적병리과정.근년연구발현,VEGF여신소관간질병변유관,기삼여신간질세포외기질적합성여강해.인차,VEGF재신소관손상중적중요작용축점피중시.해문취VEGF여신소관간질손상적연구진전작일종술.
Vascular endothelial growth factors (VEGF) are cytokines that leading to endothelial cell differentiation,proliferation,migration,and increase vascular permeability,which take part in the pathological process of microvascular.Recent studies have found that VEGF have close relationship with tubulointerstitial pathological changes.VEGF take part in the renal interstitial extracellular matrix synthesis and degradation.Therefore,we take more attention to the important role of VEGF in renal tubular damage.The present review will outline the current understanding of VEGF in the tubulointerstitial injury.
