中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2009年
7期
1239-1240
,共2页
石世强%何强先%桑更生%陈以强%张隽
石世彊%何彊先%桑更生%陳以彊%張雋
석세강%하강선%상경생%진이강%장준
血压%谷峰比值%平滑指数%坎地沙坦酯
血壓%穀峰比值%平滑指數%坎地沙坦酯
혈압%곡봉비치%평활지수%감지사탄지
Blood pressure%T/P rate of blood pressure%Smoothness index%Candesartan cliexetil
目的 探讨坎地沙坦酯治疗轻中度原发性高血压的疗效及对患者血压谷峰比值和平滑指数的影响.方法 50例轻中度原发性高血压患者,口服坎地沙坦酯8 mg,每天1次,疗程4周,于治疗前后进行24h动态血压监测并计算其谷峰比值(T/P)和平滑指数.结果 治疗4周后,24 h平均收缩压(148.2±10.7)mmHg和24 h平均舒张压(97.6±6.5)mmHg、白昼平均收缩压(152.5±9.8)mmHg和平均舒张压(96.0±5.3)mmHg、夜间平均收缩压(138.3±7.6)mm Hg和平均舒张压(89.2±8.3)mm Hg、收缩压负荷值(87.5±12.2)%和舒张压负荷值(36.48±26.4)%与治疗前的(130.2±7.2)mm Hg、(79.5±7.8)mm Hg、(133.4±7.2)mm Hg、(81.8±6.6)mm Hg、(121.9±7.3)mm Hg、(72.1±7.4)mm Hg、(84.7±9.9)%、(26.7±8.3)%比较差异均有统计学意义(均P<0.01);治疗后收缩压和舒张压T/P分别为70%和63%、平滑指数分别为(1.21±0.82)和(1.13±0.51),均符合要求.结论 坎地沙坦酯治疗原发性高血压安全有效,均能获得良好的T/P比值及平滑指数.
目的 探討坎地沙坦酯治療輕中度原髮性高血壓的療效及對患者血壓穀峰比值和平滑指數的影響.方法 50例輕中度原髮性高血壓患者,口服坎地沙坦酯8 mg,每天1次,療程4週,于治療前後進行24h動態血壓鑑測併計算其穀峰比值(T/P)和平滑指數.結果 治療4週後,24 h平均收縮壓(148.2±10.7)mmHg和24 h平均舒張壓(97.6±6.5)mmHg、白晝平均收縮壓(152.5±9.8)mmHg和平均舒張壓(96.0±5.3)mmHg、夜間平均收縮壓(138.3±7.6)mm Hg和平均舒張壓(89.2±8.3)mm Hg、收縮壓負荷值(87.5±12.2)%和舒張壓負荷值(36.48±26.4)%與治療前的(130.2±7.2)mm Hg、(79.5±7.8)mm Hg、(133.4±7.2)mm Hg、(81.8±6.6)mm Hg、(121.9±7.3)mm Hg、(72.1±7.4)mm Hg、(84.7±9.9)%、(26.7±8.3)%比較差異均有統計學意義(均P<0.01);治療後收縮壓和舒張壓T/P分彆為70%和63%、平滑指數分彆為(1.21±0.82)和(1.13±0.51),均符閤要求.結論 坎地沙坦酯治療原髮性高血壓安全有效,均能穫得良好的T/P比值及平滑指數.
목적 탐토감지사탄지치료경중도원발성고혈압적료효급대환자혈압곡봉비치화평활지수적영향.방법 50례경중도원발성고혈압환자,구복감지사탄지8 mg,매천1차,료정4주,우치료전후진행24h동태혈압감측병계산기곡봉비치(T/P)화평활지수.결과 치료4주후,24 h평균수축압(148.2±10.7)mmHg화24 h평균서장압(97.6±6.5)mmHg、백주평균수축압(152.5±9.8)mmHg화평균서장압(96.0±5.3)mmHg、야간평균수축압(138.3±7.6)mm Hg화평균서장압(89.2±8.3)mm Hg、수축압부하치(87.5±12.2)%화서장압부하치(36.48±26.4)%여치료전적(130.2±7.2)mm Hg、(79.5±7.8)mm Hg、(133.4±7.2)mm Hg、(81.8±6.6)mm Hg、(121.9±7.3)mm Hg、(72.1±7.4)mm Hg、(84.7±9.9)%、(26.7±8.3)%비교차이균유통계학의의(균P<0.01);치료후수축압화서장압T/P분별위70%화63%、평활지수분별위(1.21±0.82)화(1.13±0.51),균부합요구.결론 감지사탄지치료원발성고혈압안전유효,균능획득량호적T/P비치급평활지수.
Objective To study the T/P rate and smoothness index of Candesartan Cliexetil on slight and middle essential hypertension. Methods 50 patients with slight and middle essential hypertension were treated by Candesartan Cliexetil 8mg taken orally everyday,the course of treatment was 4 weeks. 24h ambulatory blood pressure monitoring(ABPM) was given before and after treatment, the T/P rate and smoothness index were calculated. Results Four weeks after treatment, 24h SBP(148.2±10.7) mm Hg and 24 h D BP (97.6±6.5) mm Hg, dSBP(152.5±9.8) mm Hg and dDBP(96.0±5.3) mm Hg, nSBP(138.3±7.6) mm Hg and nDBP(89.2±8.3) mm Hg, SBP load (87.5±12.2) % and DBP load (36.48±26.4) % with pre-treatment (130.2±7.2) mm Hg, (79.5±7.8) mm Hg, (133.4±7.2)mm Hg, (81.8±6.6)mm Hg,(121.9±7.3) mm Hg, (72.1±7.4) mm Hg, (84.7±9.9)%,(26.7 ±8.3) % have significant difference(P < 0.01). T/P rates were SBP 70% and DBP 63%. Smoothness indexes were SBP(1.21±0.82) and DBP(1.13±0.51). Conclusion Candesartan cilexetil in the treatment of essential hyper-tension is safe and effective,can get a good T/P ratio and smoothness index.
