CAJ | 학술논문

目的探讨不同强度窄带噪声暴露对豚鼠畸变产物耳声发射(DPOAE)的影响.方法雄性健康豚鼠60只,随机均分为3组,105 dBA组、110 dBA组和115 dBA组,暴露时间均为3 h,实验均采用窄带噪声,中心频率4000 Hz,带宽1000 Hz.噪声暴露前2 d及暴露后15 min,采用Smart OAE测听系统检测各组豚鼠DPOAE.结果随着噪声暴露量增加,豚鼠各畸变频率的DPOAE幅值及通过率均呈减少的趋势.其中,105 dBA组和110 dBA组在畸变频率1409 Hz处,105 dBA组和115 dBA组在畸变频率499、704、1003、1409 Hz处,噪声暴露后的DPOAE幅值和通过率差异有统计学意义(P<0.05).结论 4000 Hz窄带噪声暴露后DPOAE改变首先出现在高频,噪声强度增加可使听觉损伤由高频向低频延展.
목적 탐토불동강도착대조성폭로대돈서기변산물이성발사(DPOAE)적영향.방법 웅성건강돈서60지,수궤균분위3조,105 dBA조、110 dBA조화115 dBA조,폭로시간균위3 h,실험균채용착대조성,중심빈솔4000 Hz,대관1000 Hz.조성폭로전2 d급폭로후15 min,채용Smart OAE측은계통검측각조돈서DPOAE.결과 수착조성폭로량증가,돈서각기변빈솔적DPOAE폭치급통과솔균정감소적추세.기중,105 dBA조화110 dBA조재기변빈솔1409 Hz처,105 dBA조화115 dBA조재기변빈솔499、704、1003、1409 Hz처,조성폭로후적DPOAE폭치화통과솔차이유통계학의의(P<0.05).결론 4000 Hz착대조성폭로후DPOAE개변수선출현재고빈,조성강도증가가사은각손상유고빈향저빈연전.
Objective To study the effect of distortion product otoacoustic emission (DPOAE) on guinea pigs exposed to narrow band noise of different intensity. Methods Sixty healthy male guinea pigs were randomly divided into 3 groups: the 105 dBA group, the 110 dBA group and the 115 dBA group. The duration of exposure for all the groups was 3 hours and noise spectrum was narrow - band, with a mid - frequency of 4 000Hz and band-width of 1000 Hz. Two days before and 15 minutes after noise exposure, DPOAE of guinea pigs was measured by means of Smart OAE Hearing Test System. Results With increased intensity in noise exposure, DPOAE amplitude and throughput of guinea pigs at all the distortion frequencies showed a decreased tendency. For the 105 dBA group and the 110 dBA group at the distortion frequency of 1 409 Hz, and for the 105 dBA group and the 115 dBA group at frequencies of 499 Hz,704 Hz,1 003 Hz, and 1 409 Hz, the difference in DPOAE amplitude and throughput after exposure all had statistically significance (P<0.05). Conclusions Following exposure to 4 000Hz narrow band noise, DPOAE began to change at high frequencies and heating damage extended from higher frequency to lower frequencies as noise level increased.