肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
7期
457-459
,共3页
食管肿瘤%三维适型放疗%丹参注射液%顺铂
食管腫瘤%三維適型放療%丹參註射液%順鉑
식관종류%삼유괄형방료%단삼주사액%순박
Esophageal neoplasms%3D-radiotherapy%Salvia miltiorrhiza injection%DDP
目的 观察丹参注射液同步三维适形放疗(3DCRT)治疗食管癌疗效和不良反应.方法 62例食管癌患者随机分为丹参注射液同步放疗组(A组)和顺铂同步放疗组(B组).均采用加速器6 MV的X线3DCRT,总剂量60 ～ 70 Gy.A组放疗前3d开始静脉滴注丹参注射液20 ml/d,至放疗结束；B组放疗同时静脉滴注顺铂30 mg/m2,每周3次,至放疗结束.结果 A组的近期有效率为71.0％(22/31),与B组接近[74.2％(23/31)](x2=0.522,P＞0.05),多种不良反应发生率降低,A组2、3年生存率分别为66.7％和43.3％,优于B组的55.3％和16.7％(x2=3.18,x2=4.526,均P＞ 0.05).结论 丹参注射液同步3DCRT方案对中晚期食管癌有较好疗效,值得临床推广.
目的 觀察丹參註射液同步三維適形放療(3DCRT)治療食管癌療效和不良反應.方法 62例食管癌患者隨機分為丹參註射液同步放療組(A組)和順鉑同步放療組(B組).均採用加速器6 MV的X線3DCRT,總劑量60 ～ 70 Gy.A組放療前3d開始靜脈滴註丹參註射液20 ml/d,至放療結束；B組放療同時靜脈滴註順鉑30 mg/m2,每週3次,至放療結束.結果 A組的近期有效率為71.0％(22/31),與B組接近[74.2％(23/31)](x2=0.522,P＞0.05),多種不良反應髮生率降低,A組2、3年生存率分彆為66.7％和43.3％,優于B組的55.3％和16.7％(x2=3.18,x2=4.526,均P＞ 0.05).結論 丹參註射液同步3DCRT方案對中晚期食管癌有較好療效,值得臨床推廣.
목적 관찰단삼주사액동보삼유괄형방료(3DCRT)치료식관암료효화불량반응.방법 62례식관암환자수궤분위단삼주사액동보방료조(A조)화순박동보방료조(B조).균채용가속기6 MV적X선3DCRT,총제량60 ～ 70 Gy.A조방료전3d개시정맥적주단삼주사액20 ml/d,지방료결속；B조방료동시정맥적주순박30 mg/m2,매주3차,지방료결속.결과 A조적근기유효솔위71.0％(22/31),여B조접근[74.2％(23/31)](x2=0.522,P＞0.05),다충불량반응발생솔강저,A조2、3년생존솔분별위66.7％화43.3％,우우B조적55.3％화16.7％(x2=3.18,x2=4.526,균P＞ 0.05).결론 단삼주사액동보3DCRT방안대중만기식관암유교호료효,치득림상추엄.
Objective To evaluate the efficacy and toxicity of 3D-radiotherapy combined with salvia miltiorrhiza injection to treat esophageal cancer. Methods 62 patients were randomly divided into group A and B.Group A were treated with 3D-radiotherapy (60-70 Gy) combined with salvia miltiorrhiza injection (20 ml/d).Group B were treated with 3D-radiotherapy (60-70 Gy) combined with cisplatin (30 mg/m2,d1-d3/w).Results The 71.0 ％(22/31 ) recent effective rate of group A was obtained[74.2 ％(22/31) of group B],the 2 to 3 years survival rates were 66.7 ％ and 43.3 ％ respectively (55.3 ％ and 16.7 ％ of group B). Conclusion The effect is good using 3D-radiotherapy combined with salvia miltiorrhiza injection to treat esophageal cancer.
