肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2009年
3期
202-204
,共3页
胃肿瘤%危险凶素%癌前疾病%移民流行病学%二项分布%泊松分布
胃腫瘤%危險兇素%癌前疾病%移民流行病學%二項分佈%泊鬆分佈
위종류%위험흉소%암전질병%이민류행병학%이항분포%박송분포
Stomach neoplasms%Risk factors%Precancerous disease%Epidemiology%Binomial distribution%Poisson distribution
目的 分析甘肃省武威市胃癌高发的危险因素,为胃癌的一级预防提供病因学线索.方法 应用移民流行病学研究方法对移居新疆维吾尔自治区奇台县的武威籍居民因胃癌死亡的情况进行调查;地区聚集性分析根据胃癌死亡登记资料采用Poisson分布模型拟合,并用频数分布拟合优度的x2检验进行验证;家族聚集性分析,采用二项分布(p+q)n数学模型拟合,实际发病数与理论数的差异比较用x2检验;用历史性队列研究方法观察四种癌前疾病的癌变情况;采用紫外分光光度法和盐酸萘乙二胺法分别测定饮用水中的硝酸盐氮和亚硝酸盐氮含量.结果 移民胃癌一代及后裔均较祖籍武威市同期的死亡率为低,但高于定居地奇台县同期死亡率水平;胃癌在以村为单位和家族中呈现地区和家族聚集性;胃息肉、萎缩性胃炎、胃溃疡、残胃等四种痛前疾病的人年癌变率依次为0.459%、0.431%、0.381%、0.178%;人群特异危险度百分比依次为41.26%、29.35%、4.68%、3.39%;硝酸盐氮和亚硝酸盐氮无论是地表水还是浅井水武威市均明显高于兰州市(P＜0.01).结论 移民一代及后裔的胃癌死亡率低于祖籍但高于定居地的水平,胃癌发病存在地区与家族聚集性;居民饮用水中富含硝酸盐氮和亚硝酸盐氮;胃息肉、萎缩性胃炎、胃溃疡、残胃等四种胃部慢性疾病为武威市胃癌高发的内在因素.
目的 分析甘肅省武威市胃癌高髮的危險因素,為胃癌的一級預防提供病因學線索.方法 應用移民流行病學研究方法對移居新疆維吾爾自治區奇檯縣的武威籍居民因胃癌死亡的情況進行調查;地區聚集性分析根據胃癌死亡登記資料採用Poisson分佈模型擬閤,併用頻數分佈擬閤優度的x2檢驗進行驗證;傢族聚集性分析,採用二項分佈(p+q)n數學模型擬閤,實際髮病數與理論數的差異比較用x2檢驗;用歷史性隊列研究方法觀察四種癌前疾病的癌變情況;採用紫外分光光度法和鹽痠萘乙二胺法分彆測定飲用水中的硝痠鹽氮和亞硝痠鹽氮含量.結果 移民胃癌一代及後裔均較祖籍武威市同期的死亡率為低,但高于定居地奇檯縣同期死亡率水平;胃癌在以村為單位和傢族中呈現地區和傢族聚集性;胃息肉、萎縮性胃炎、胃潰瘍、殘胃等四種痛前疾病的人年癌變率依次為0.459%、0.431%、0.381%、0.178%;人群特異危險度百分比依次為41.26%、29.35%、4.68%、3.39%;硝痠鹽氮和亞硝痠鹽氮無論是地錶水還是淺井水武威市均明顯高于蘭州市(P＜0.01).結論 移民一代及後裔的胃癌死亡率低于祖籍但高于定居地的水平,胃癌髮病存在地區與傢族聚集性;居民飲用水中富含硝痠鹽氮和亞硝痠鹽氮;胃息肉、萎縮性胃炎、胃潰瘍、殘胃等四種胃部慢性疾病為武威市胃癌高髮的內在因素.
목적 분석감숙성무위시위암고발적위험인소,위위암적일급예방제공병인학선색.방법 응용이민류행병학연구방법대이거신강유오이자치구기태현적무위적거민인위암사망적정황진행조사;지구취집성분석근거위암사망등기자료채용Poisson분포모형의합,병용빈수분포의합우도적x2검험진행험증;가족취집성분석,채용이항분포(p+q)n수학모형의합,실제발병수여이론수적차이비교용x2검험;용역사성대렬연구방법관찰사충암전질병적암변정황;채용자외분광광도법화염산내을이알법분별측정음용수중적초산염담화아초산염담함량.결과 이민위암일대급후예균교조적무위시동기적사망솔위저,단고우정거지기태현동기사망솔수평;위암재이촌위단위화가족중정현지구화가족취집성;위식육、위축성위염、위궤양、잔위등사충통전질병적인년암변솔의차위0.459%、0.431%、0.381%、0.178%;인군특이위험도백분비의차위41.26%、29.35%、4.68%、3.39%;초산염담화아초산염담무론시지표수환시천정수무위시균명현고우란주시(P＜0.01).결론 이민일대급후예적위암사망솔저우조적단고우정거지적수평,위암발병존재지구여가족취집성;거민음용수중부함초산염담화아초산염담;위식육、위축성위염、위궤양、잔위등사충위부만성질병위무위시위암고발적내재인소.
Objective The incidence of gastric carcinoma(GC) has significantly difference in different areas because it has different cancerogenic and stimulative factors in different areas. Through displaying the epidemic factors of popular GC in Wuwei city, it can supply etiological clue of the first-level prevention to GC. Methods The research methods about epidemiology of migrant were used to investigate the case fatality rate of GC about the people in Qitai county of Xinjiang province who immigrated from Wuwei. According to the information of GC-death registered, we fitted local cluster analyse with Possion-distribution model, and then the results were processed with case-control study of chi square test; Binomial distribution (p+q)n model was used to familial cluster analysis, and the statistical method of X2 was used to compare the difference between the actual incidence and theoretical incidence of GC. Adopting the history arrangement analysis, the canceration of four precancerous diseases were observed. Nitrogen content of nitrate and nitrite in drinking water were respectively measured by using ultraviolet spectrophotometric and hydrochloride naphthaline ethylenediamine methods. Results The death rates of GC of the first-generation and their descendants of emigrants were much lower than those contemporary beings in Wuwei, but were higher than those contemporary beings in Qitai country. The prevalence of GC had region and familial aggregation. The year canceration proportion of people who had precancerous diseases such as stomach polypus, atrophyic gastritis,gastric ulcer, and remnant stomach were 0.459 %, 0.431%, 0.381% and 0.178 % respectively. The percentage of crowd attributive risk were 41.26 %, 29.35 %, 4.68 % and 3.39 % respectively. Nitrogen contents of nitrate and nitrite either in surface water or in shallow water were significantly higher in Wuwei city than that in Lanzhou city (P＜0.01). Conclusion Death rates of GC for the emigrants of the first-generation and their descendants are much lower than their ancestry, but higher than those of the generation in Qitai county. The prevalence of GC has region and familial aggregation. It is the immanent factor of popular GC in Wuwei City that there are higher contents of nitrogen content of nitrate and nitrite in residenter' s drinking water and four precancerous diseases including stomach polypus, atrophyic gastritis, gastric ulcer,and remnant stomach.
