CAJ | 학술논문

探讨代谢综合征(MS)患者血清Apelin的变化.用ELISA法测定血清Apelin.MS组Apelin明显升高(P＜0.01),2型糖尿病MS组Apelin明显高于糖调节受损MS组和超重或肥胖者[(475.8±37.3对451.5±54.3及430.3±52.1)ng/L,P＜0.01].多元逐步回归分析显示,胰岛素抵抗、体重指数和总胆固醇是Apelin独立相关因素.MS多种代谢组分异常与Apelin升高密切相关,可能是胰岛素抵抗加重所致.
탐토대사종합정(MS)환자혈청Apelin적변화.용ELISA법측정혈청Apelin.MS조Apelin명현승고(P＜0.01),2형당뇨병MS조Apelin명현고우당조절수손MS조화초중혹비반자[(475.8±37.3대451.5±54.3급430.3±52.1)ng/L,P＜0.01].다원축보회귀분석현시,이도소저항、체중지수화총담고순시Apelin독립상관인소.MS다충대사조분이상여Apelin승고밀절상관,가능시이도소저항가중소치.
The changes of serum apelin in patients with metabolic syndrome were investigated. The level of fasting serum apelin was determined by ELISA assay.The level of serum apelin was raised obviously in patients with metabolic syndrome(MS).Moreover,the level of serum apelin in patients with type 2 diabetes mellitus was higher than those in cases of MS with impaired glucose regulation and the group of subjects with overweight/obesity [ (475.8±37.3 vs 451.5±54.3 and 430.3±52.1 ) ng/L,P＜0.01 ].In a multiple step-wise regression analysis,In homeostasis model assessment of insulin resistance ( HOMA-IR),body mass index,and total cholesterol were independent factors of apelin.The increased serum apelin was closely related to metabolic abnormalities in metabolic syndrome.The increased insulin resistance might cause the raised level of serum apelin in patients with MS.