CAJ | 학술논문

目的运用多体素质子磁共振波谱(proton magnetic resonance spectroscopy,1H-MRS)技术研究肾虚对老年人听皮层代谢的影响.方法从南京军区福州总医院体检人员中选择受试者,分为老年组30例,对照组20例,两组受试者均予以纯音听阈检测和“肾虚”程度评价,再运用1H-MRS行双侧听皮层检测,在工作站上测量N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)、乳酸(Lac)及NAA/Cr、Cho/Cr、NAA/Cho、Lac/Cr等比值,进行统计学分析.比较两组间肾虚程度及上述听皮层代谢相关指标,分析老年人听皮层代谢变化与“肾虚”程度的关系.结果与青年对照组比较,老年组高频听阈、肾虚评分均明显提高,差异有统计学意义(t=6.335、19.558,P＜0.05)；听皮层NAA/Cr下降、Cho/Cr上升,差异无统计学意义(t=1.415、0.927,P＞0.05); NAA/Cho明显下降,Lac/Cr上升,差异均有统计学意义(t=2.90、44.871,P＜0.05).老年组听皮层NAA/Cho和肾虚积分呈负相关(r=-0.773,P=0.025).结论老年人“肾虚”程度与听皮层神经元的丢失和听力减退有一定的相关性,这可能与发生在老年人的听觉障碍有关.
목적 운용다체소질자자공진파보(proton magnetic resonance spectroscopy,1H-MRS)기술연구신허대노년인은피층대사적영향.방법 종남경군구복주총의원체검인원중선택수시자,분위노년조30례,대조조20례,량조수시자균여이순음은역검측화“신허”정도평개,재운용1H-MRS행쌍측은피층검측,재공작참상측량N-을선천문동안산(NAA)、기산(Cr)、담감(Cho)、유산(Lac)급NAA/Cr、Cho/Cr、NAA/Cho、Lac/Cr등비치,진행통계학분석.비교량조간신허정도급상술은피층대사상관지표,분석노년인은피층대사변화여“신허”정도적관계.결과 여청년대조조비교,노년조고빈은역、신허평분균명현제고,차이유통계학의의(t=6.335、19.558,P＜0.05)；은피층NAA/Cr하강、Cho/Cr상승,차이무통계학의의(t=1.415、0.927,P＞0.05); NAA/Cho명현하강,Lac/Cr상승,차이균유통계학의의(t=2.90、44.871,P＜0.05).노년조은피층NAA/Cho화신허적분정부상관(r=-0.773,P=0.025).결론 노년인“신허”정도여은피층신경원적주실화은력감퇴유일정적상관성,저가능여발생재노년인적은각장애유관.
Objective To investigate the effects of kidney-deficiency on auditory cortex metabolism in the elderly by using the proton magnetic resonance spectroscopy(1H-MRS).Methods 50 volunteers,including 20 young subjects and 30 older subjects matched for gender,were measured by pure tone audiometry、“kidney-deficiency”-related test and were executed 3.0 T multi-voxel 1H-MRS tests,The ratios of N-acetylaspartate (NAA),choline (Cho) and lactate (Lac) to creatine (Cr) were measured and were compared between the two groups.The t-test analysis were used for statistic process.The relationship between auditory cortex metabolism and the symptom of "kidney-deficiency" was also analyzed.Resnlts The result of "kidney-deficiency"-related test and pure tone audiometry revealed that there was significant difference between the two groups and the older subjects had the more severity "kidney-deficiency" and high-frequency hearing loss (t=6.335、19.558,P＜0.05).The NAA/Cho ratio in the auditory cortex in the older group was significantly lower than that in the younger group (t=2.90,P＜0.05).There were no significant differences between two groups for the ratios of NAA/Cr and Cho/Cr (t=1.415、0.927,P＞0.05).Decrease of the ratio of NAA/Cho in the older group is significantly related with "kidneT-deficiency"(r=- 0.773,P=0.025).Conclusion "kidney-deficiency" play a very important role in the hearing loss and reduction of the number of neurons in auditory cortex of older healthy subjects.It suggests one possible underlying mechanism for the speech perception difficulties exhibited by aging adults.