CAJ | 학술논문

目的探讨胃肠道间质瘤(Gastric intestinal tumor,GIST)的临床表现与病理特点的关系.方法回顾分析手术切除后病理诊断为GIST的86例患者的临床表现及病理特征.结果 86例切除的胃肠道间质瘤中10例为良性(包括7例潜在恶性),肿物平均直径2.0 cm,16例为低度恶性,肿物平均直径2.9 cm,60例为高度恶性,肿物平均直径8.6 cm.其中53.5%(49/86)来源于胃,27.4%(23/86)来源于小肠,4.7%(4/86)来源于大肠,11.6%(10/86)来源于网膜、腹腔.良性组肿瘤无明显出血、坏死,细胞无异型性,核分裂少见.恶性组肿瘤可见出血、坏死,细胞异型性明显,核分裂多见.免疫组化指标测定CD117阳性80例,占93.0%,CD34阳性68例,占79.1%,SMA阳性13例,占15.1%,S100阳性4例,占4.7%.结论 GIST主要发生在胃、肠道和腹腔,CD117和CD34阳性是诊断GIST最有价值的免疫标记物.GIST的恶性程度与肿瘤的大小、核分裂数和发病部位密切相关.
목적 탐토위장도간질류(Gastric intestinal tumor,GIST)적림상표현여병리특점적관계.방법 회고분석수술절제후병리진단위GIST적86례환자적림상표현급병리특정.결과 86례절제적위장도간질류중10례위량성(포괄7례잠재악성),종물평균직경2.0 cm,16례위저도악성,종물평균직경2.9 cm,60례위고도악성,종물평균직경8.6 cm.기중53.5%(49/86)래원우위,27.4%(23/86)래원우소장,4.7%(4/86)래원우대장,11.6%(10/86)래원우망막、복강.량성조종류무명현출혈、배사,세포무이형성,핵분렬소견.악성조종류가견출혈、배사,세포이형성명현,핵분렬다견.면역조화지표측정CD117양성80례,점93.0%,CD34양성68례,점79.1%,SMA양성13례,점15.1%,S100양성4례,점4.7%.결론 GIST주요발생재위、장도화복강,CD117화CD34양성시진단GIST최유개치적면역표기물.GIST적악성정도여종류적대소、핵분렬수화발병부위밀절상관.
Objective To explore the histogenesis,immunohistochemical and clinic pathological characteristics of gastrointestinal stromal tumor.Methods The postoperative pathological findings of 86 cases of gastrointestinal stromal tumor were analyzed retrospectively.Results The 86 cases of GIST were consisted of 10 benign cases,16 low-degree malignant cases and 60 high-degree malignant cases.53.5%(49/86) of which were from stomach,27.4%(23/86) from small intestine,4.7 %(4/86) from colon and 11.6%(10/86)from mesenteric.Innocuousness tumor group had no manifest bleeding and necrosis.Cells had no heteromorphism and less caryocinesia.Malignacy tumor group were abundance of cellulars and haemorrhage,necrosis,heteromorphism,caryocinesia were manifest.The positive rate of CD117(80 cases) was 93.0%,the positive rate of CD34(68 cases) was 79.1%,the positive of SMA( 13 cases) was 15.1% and the positive rate of S100(4 cases) was 4.7%.Conclusion Pathologic features are different between benign and malignant gastrointestinal stromal tumor,and it is necessary to use immunohistochemical marker for differentiation the diagnosis,particurly CD117 and CD34.There is strong relationship between the GIST malignancy and its size,mitomic index and anatomic location.