中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
31期
9-12
,共4页
尹朝霞%史作霞%许京娟%王青%杨明
尹朝霞%史作霞%許京娟%王青%楊明
윤조하%사작하%허경연%왕청%양명
糖尿病,2型%周围动脉疾病%危险因素
糖尿病,2型%週圍動脈疾病%危險因素
당뇨병,2형%주위동맥질병%위험인소
Diabetes mellitus,type 2%Peripheral arterial disease%Risk factors
目的 探讨2型糖尿病患者周围动脉疾病(PAD)的患病率及传统和非传统危险因素对其影响.方法 选择病程超过1年的2型糖尿病患者共420例,以踝臂指数(ABI)≤0.90定义为有PAD,评价年龄、性别、体重指数、吸烟、高血压、糖尿病病程、糖化血红蛋白、血尿酸、三酰甘油、总胆固醇、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、高敏C反应蛋白(hs-CRP)、纤维蛋白原、尿白蛋白排泄率(UAER)等危险因素对PAD患病率的影响.结果 2型糖尿病患者PAD患病率为16.4%(69/420),PAD患者年龄偏大、糖尿病病程较长、HDL-C偏低,有高的UAER、hs-CRP和纤维蛋白原,Logistic回归可见年龄、UAER、hs-CRP、纤维蛋白原均为PAD的独立危险因素.PAD患病率在年龄<50岁、50～70岁和>70岁时分别为4.7%(2/43)、12.9%(27/209)和23.8%(40/168),在hs-CRP<1 mg/L、1～3 mg/L和>3 mg/L时分别为7.9%(14/177)、9.3%(11/118)和35.2%(44/125),在UAER正常、微量白蛋白尿和大量白蛋白尿时分别为9.7%(30/310)、34.4%(33/96)和42.9%(6/14),在纤维蛋白原≤4 g/L和>4 g/L时分别为12.1%(43/356)和40.6%(26/64).结论 2型糖尿病患者PAD的患病率较高,一些非传统危险因素也参与PAD的发生.
目的 探討2型糖尿病患者週圍動脈疾病(PAD)的患病率及傳統和非傳統危險因素對其影響.方法 選擇病程超過1年的2型糖尿病患者共420例,以踝臂指數(ABI)≤0.90定義為有PAD,評價年齡、性彆、體重指數、吸煙、高血壓、糖尿病病程、糖化血紅蛋白、血尿痠、三酰甘油、總膽固醇、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、高敏C反應蛋白(hs-CRP)、纖維蛋白原、尿白蛋白排洩率(UAER)等危險因素對PAD患病率的影響.結果 2型糖尿病患者PAD患病率為16.4%(69/420),PAD患者年齡偏大、糖尿病病程較長、HDL-C偏低,有高的UAER、hs-CRP和纖維蛋白原,Logistic迴歸可見年齡、UAER、hs-CRP、纖維蛋白原均為PAD的獨立危險因素.PAD患病率在年齡<50歲、50～70歲和>70歲時分彆為4.7%(2/43)、12.9%(27/209)和23.8%(40/168),在hs-CRP<1 mg/L、1～3 mg/L和>3 mg/L時分彆為7.9%(14/177)、9.3%(11/118)和35.2%(44/125),在UAER正常、微量白蛋白尿和大量白蛋白尿時分彆為9.7%(30/310)、34.4%(33/96)和42.9%(6/14),在纖維蛋白原≤4 g/L和>4 g/L時分彆為12.1%(43/356)和40.6%(26/64).結論 2型糖尿病患者PAD的患病率較高,一些非傳統危險因素也參與PAD的髮生.
목적 탐토2형당뇨병환자주위동맥질병(PAD)적환병솔급전통화비전통위험인소대기영향.방법 선택병정초과1년적2형당뇨병환자공420례,이과비지수(ABI)≤0.90정의위유PAD,평개년령、성별、체중지수、흡연、고혈압、당뇨병병정、당화혈홍단백、혈뇨산、삼선감유、총담고순、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)、고민C반응단백(hs-CRP)、섬유단백원、뇨백단백배설솔(UAER)등위험인소대PAD환병솔적영향.결과 2형당뇨병환자PAD환병솔위16.4%(69/420),PAD환자년령편대、당뇨병병정교장、HDL-C편저,유고적UAER、hs-CRP화섬유단백원,Logistic회귀가견년령、UAER、hs-CRP、섬유단백원균위PAD적독립위험인소.PAD환병솔재년령<50세、50～70세화>70세시분별위4.7%(2/43)、12.9%(27/209)화23.8%(40/168),재hs-CRP<1 mg/L、1～3 mg/L화>3 mg/L시분별위7.9%(14/177)、9.3%(11/118)화35.2%(44/125),재UAER정상、미량백단백뇨화대량백단백뇨시분별위9.7%(30/310)、34.4%(33/96)화42.9%(6/14),재섬유단백원≤4 g/L화>4 g/L시분별위12.1%(43/356)화40.6%(26/64).결론 2형당뇨병환자PAD적환병솔교고,일사비전통위험인소야삼여PAD적발생.
Objective To analyze the prevalence of peripheral arterial disease (PAD) in type 2 diabetic patients and its association with traditional and non-traditional risk factors. Methods A total of 420 type 2 diabetic patients with duration exceeding 1 year and without acute myocardial infarction, unstable angina,and infection were evaluated. PAD was diagnosed by ankle-brachial index ≤0.90. Risk factors included age, gender, body mass index, smoking, hypertension, diabetes duration,glycated hemoglobin A[C ( HbA_1C ), uric acid, triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol(HDL-C),high sensitive C reactive protein(hs-CRP),fibrinogen,and urinary albumin excretion rate (UAER). Results The prevalence rate of PAD was 16.4%(69/420). Older age, longer diabetes duration,lower HDL-C, higher UAER, hs-CRP and fibrinogen were associated with PAD. Multiple Logistic regression revealed that only age, UAER, hs-CRP and fibrinogen levels were independent risk factors. The prevalence rate of PAD was 4.7%(2/43), 12.9%(27/209) and 23.8%(40/168) in patients of less than 50 years old,50-70 years old and more than 70 years old, and was 7.9%( 14/177),9.3%( 11/118) and 35.2% (44/125) in different hs-CRP group (hs-CRP < 1 mg/L,l-3 mg/L, >3 mg/L), and was 9.7% (30/310) ,34.4%(33/96) and 42.9%(6/14) in normoalbuminuria, microalbuminuria and macroalbuminuria, and was 12.1%(43/356) and 40.6%(26/64) in different fibrinogen levels group (≤4 g/L and > 4 g/L). Conclusions The prevalence rate of PAD is higher in type 2 diabetic patients. Non-traditional cardiovascular risk factors may be involved in the development of PAD.
