国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2008年
z1期
17-19
,共3页
核因子-κB%肥胖%炎症
覈因子-κB%肥胖%炎癥
핵인자-κB%비반%염증
Nuclear factor kappa B%Obesity%Inflammation
核因子-κB(NF-κB)是独特的核转录因子,广泛存在于高级真核生物的各种细胞中,参与炎性反应、分化和凋亡等多种细胞反应.近年来的研究显示,NF-κB在肥胖的发病中起重要作用.NF-κB可能通过促进脂肪组织炎性反应、抑制脂肪细胞分化以及调节脂肪细胞凋亡而参与肥胖的发生与发展.
覈因子-κB(NF-κB)是獨特的覈轉錄因子,廣汎存在于高級真覈生物的各種細胞中,參與炎性反應、分化和凋亡等多種細胞反應.近年來的研究顯示,NF-κB在肥胖的髮病中起重要作用.NF-κB可能通過促進脂肪組織炎性反應、抑製脂肪細胞分化以及調節脂肪細胞凋亡而參與肥胖的髮生與髮展.
핵인자-κB(NF-κB)시독특적핵전록인자,엄범존재우고급진핵생물적각충세포중,삼여염성반응、분화화조망등다충세포반응.근년래적연구현시,NF-κB재비반적발병중기중요작용.NF-κB가능통과촉진지방조직염성반응、억제지방세포분화이급조절지방세포조망이삼여비반적발생여발전.
Nuclear factor kappa B(NF-κB)is a special nuclear transcription factor which has been discovered in many advanced eukaryotic cells.NF-κB takes part in muhiple cell processes including inflammarion,differentiation and apoptosis.Recent studies show,that NF-κB plays an important role in the pathogenesis of obesity.NF-κB may participate in the occurrence and development of obesity by facilitating in the inflammation in adipose tissue,repressing the differentiation and regulating the apoptosis of adipocytes.
