CAJ | 학술논문

目的研究抗凋亡蛋白Livin和促凋亡因子Smac在非霍奇金淋巴瘤(NHL)中的表达及其与临床特征和预后间的关系.方法应用免疫组织化学方法检测31例NHL患者Livin和Smac表达情况,并将其与临床随访进行临床特征和生存预后关系的研究.结果 Livin蛋白高表达的患者多为有B症状、Ⅲ/Ⅳ期和国际预后指数(IPI)高危者,而Smac蛋白高表达患者多为无症状、Ⅰ/Ⅱ期和IPI低危者.但Liyin和Smac蛋白表达均与性别和年龄无相关关系.Livin和Smac两者之间无相关关系(r=0.003,P＞0.05).Livin蛋白低表达患者的生存情况明显好于高表达患者,而Smac蛋白高表达的生存情况明奇好于低表达患者.结论 Livin表达与NHL不良临床特征及预后相关,而Smac表达与良好的临床特征及预后有关.
목적 연구항조망단백Livin화촉조망인자Smac재비곽기금림파류(NHL)중적표체급기여림상특정화예후간적관계.방법 응용면역조직화학방법검측31례NHL환자Livin화Smac표체정황,병장기여림상수방진행림상특정화생존예후관계적연구.결과 Livin단백고표체적환자다위유B증상、Ⅲ/Ⅳ기화국제예후지수(IPI)고위자,이Smac단백고표체환자다위무증상、Ⅰ/Ⅱ기화IPI저위자.단Liyin화Smac단백표체균여성별화년령무상관관계.Livin화Smac량자지간무상관관계(r=0.003,P＞0.05).Livin단백저표체환자적생존정황명현호우고표체환자,이Smac단백고표체적생존정황명기호우저표체환자.결론 Livin표체여NHL불량림상특정급예후상관,이Smac표체여량호적림상특정급예후유관.
Objective To study the expression and clinical significance of Livin ( anti-apoptosis protein) and Smac (promoting apoptosis factor) in patients with the non-Hodgkin lymphoma (NHL).Methods The expression of Livin and Smac were detected by immunohistochemical staining(SP) assay in 31 patients with NHL, and the relationship between Livin/Smac and clinical staging, IPI and prognosis were analyzed. Results The patients with positive expression of Livin had B symptom, high risk IPI, late clinical staging (Ⅲ/Ⅳ stage) and short survival time, while the ones with positive expression of Smac had no B symptom, early clinical staging( Ⅰ /Ⅱ stage), low risk IPI and good prognosis. The expressions of both Livin and Smac were not related to gender and age. Expression of Livin was not correlated to that of Smac (r =0.003,P ＞0.05). Conclusion For patients with NHL, the expression of Livin protein was related to poor prognosis and adverse clinical features, whereas the expression of Smac protein was related to good prognosis and clinical feature.