中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2001年
2期
105-107
,共3页
时景璞%王昕%张群弟%李征远%王桂花%杨志齐%孙宏章%郭乃全%郑力国%徐占民%梁争论%吴晓音
時景璞%王昕%張群弟%李徵遠%王桂花%楊誌齊%孫宏章%郭迺全%鄭力國%徐佔民%樑爭論%吳曉音
시경박%왕흔%장군제%리정원%왕계화%양지제%손굉장%곽내전%정력국%서점민%량쟁론%오효음
重组酵母乙型肝炎疫苗%抗体阳转率%抗体几何平均滴度
重組酵母乙型肝炎疫苗%抗體暘轉率%抗體幾何平均滴度
중조효모을형간염역묘%항체양전솔%항체궤하평균적도
目的 探讨重组酵母乙型肝炎疫苗(YDV)对成人的免疫效果及安全性。方法 在辽宁省北票市部分学校选择一般健康状况良好，乙型肝炎表面抗原(HBsAg)、乙型肝炎表面抗体(抗-HBs)、乙型肝炎核心抗体(抗-HBc)三项指标均为阴性，体温正常的22～58岁的教师，随机抽取124名，按0、1、6个月程序，每剂5 μg/0.5 ml接种卫生部北京生物制品研究所生产的重组酵母乙型肝炎疫苗。 结果 免疫后3、7、12个月时，抗-HBs阳转率分别为35.0%、83.3%、67.2%(P＜0.01)。抗-HBs平均滴度分别为12.63 mIU/ml、402.04 mIU/ml、70.28 mIU/ml(P＜0.01)；抗-HBs阳转率及其滴度均在7个月时达到高峰，以后又急剧下降。免疫后3、7、12个月时，女性抗-HBs阳转率和滴度均高于男性。但仅抗-HBs滴度在免疫后3个月时两者之间差异有显著性；小于35岁组的抗体阳转率高于35岁以上组，但仅在免疫后12个月时两者之间差异有显著性；而该两个年龄组间的抗-HBs滴度差异无显著性；免疫3 d后局部和全身未见不良反应。结论 重组酵母乙型肝炎疫苗对成人具有良好的免疫原性和安全性，其抗-HBs持续时间有待进一步观察。
目的 探討重組酵母乙型肝炎疫苗(YDV)對成人的免疫效果及安全性。方法 在遼寧省北票市部分學校選擇一般健康狀況良好，乙型肝炎錶麵抗原(HBsAg)、乙型肝炎錶麵抗體(抗-HBs)、乙型肝炎覈心抗體(抗-HBc)三項指標均為陰性，體溫正常的22～58歲的教師，隨機抽取124名，按0、1、6箇月程序，每劑5 μg/0.5 ml接種衛生部北京生物製品研究所生產的重組酵母乙型肝炎疫苗。 結果 免疫後3、7、12箇月時，抗-HBs暘轉率分彆為35.0%、83.3%、67.2%(P＜0.01)。抗-HBs平均滴度分彆為12.63 mIU/ml、402.04 mIU/ml、70.28 mIU/ml(P＜0.01)；抗-HBs暘轉率及其滴度均在7箇月時達到高峰，以後又急劇下降。免疫後3、7、12箇月時，女性抗-HBs暘轉率和滴度均高于男性。但僅抗-HBs滴度在免疫後3箇月時兩者之間差異有顯著性；小于35歲組的抗體暘轉率高于35歲以上組，但僅在免疫後12箇月時兩者之間差異有顯著性；而該兩箇年齡組間的抗-HBs滴度差異無顯著性；免疫3 d後跼部和全身未見不良反應。結論 重組酵母乙型肝炎疫苗對成人具有良好的免疫原性和安全性，其抗-HBs持續時間有待進一步觀察。
목적 탐토중조효모을형간염역묘(YDV)대성인적면역효과급안전성。방법 재요녕성북표시부분학교선택일반건강상황량호，을형간염표면항원(HBsAg)、을형간염표면항체(항-HBs)、을형간염핵심항체(항-HBc)삼항지표균위음성，체온정상적22～58세적교사，수궤추취124명，안0、1、6개월정서，매제5 μg/0.5 ml접충위생부북경생물제품연구소생산적중조효모을형간염역묘。 결과 면역후3、7、12개월시，항-HBs양전솔분별위35.0%、83.3%、67.2%(P＜0.01)。항-HBs평균적도분별위12.63 mIU/ml、402.04 mIU/ml、70.28 mIU/ml(P＜0.01)；항-HBs양전솔급기적도균재7개월시체도고봉，이후우급극하강。면역후3、7、12개월시，녀성항-HBs양전솔화적도균고우남성。단부항-HBs적도재면역후3개월시량자지간차이유현저성；소우35세조적항체양전솔고우35세이상조，단부재면역후12개월시량자지간차이유현저성；이해량개년령조간적항-HBs적도차이무현저성；면역3 d후국부화전신미견불량반응。결론 중조효모을형간염역묘대성인구유량호적면역원성화안전성，기항-HBs지속시간유대진일보관찰。
Objective To study the immunogenicity and safety of recombinant yeast-derived hepatitis B vaccine (YDV) on adults. Methods One hundred twenty-four healthy teachers of 22-58 years old, were randomly selected in Beipiao city, Liaoning province. Their HBsAg,anti-HBs and anti-HBc were all negative and temperature was normal. They were vaccinated with 5 μg/0.5 ml of YDV, which was made in Beijing Institute of Biologic Products, at 0，1，6 months. Results The positive rates of anti-HBs were 35.0%，83.3%， 67.2% (P＜0.01) with the mean geometric titre(GMT) of anti-HBs 12.63 mIU/ml、402 .04 mIU/ml and 70.28 mIU/ml (P＜0.01) at 3th，7th，12th months respectively. The positive rates of anti-HBs and GMT of anti-HBs became the highest at 7th month, then began to decrease sharply. At 3th，7th，12th months the positive rates of anti-HBs and GMT of anti-HBs were higher on female compared to male, but only GMT of anti-HBs was significantly different at 3th month; the positive rates of anti-HBs in below 35 years old group was higher than 35 and over years old group, but it was significantly different only at 12th month. GMT of anti-HBs between the two groups was no obvious difference. Local or systematic addictive reactions were not found in all the subjects in 3 days after injection. Conclusion YDV is effective and safety to adults. The duration of anti-HBs should be further observed.
