CAJ | 학술논문

目的　探讨精神分裂症患者血浆精氨酸加压素（AVP）的变化。方法　采用放射免疫法测定38例精神分裂症患者及22例正常对照者的血浆AVP含量。结果　精神分裂症患者血浆AVP含量较对照组低，差异非常显著（t=9. 59，P＜0.01）；精神分裂症患者氯氮平治疗4周时其血浆AVP含量较治疗前显著增高（t=2.37，P＜0.05），氯丙嗪治疗前后则变化不明显（t=0.85， P＜0.05）。结论　精神分裂症患者存在AVP代谢异常的现象；氯氮平等抗精神药物对体内AVP代谢有一定的影响。
목적　탐토정신분렬증환자혈장정안산가압소（AVP）적변화。 방법　 채용방사면역법측정38례정신분렬증환자급22례정상대조자적혈장AVP함량。결과　 정신분렬증환자혈장AVP함량교대조조저，차이비상현저（t=9. 59，P＜0.01）；정신분렬증환자록담평치료4주시기혈장AVP함량교치료전현저증고（t=2.37，P＜0.05），록병진치료전후칙변화불명현（t=0.85， P＜0.05）。결론　 정신분렬증환자존재AVP대사이상적현상；록담평등항정신약물대체내AVP대사유일정적영향。
Objective To explore the changes of plasmatic AVP in schizophernic patients. Methods Plasmatic AVP concentration was determined with radioimmunoassay in 38 Schizophrenic Patients and 22 normal controls. Result Compared with normal controls, plasmatic AVP concentration in schizophrenic patients was significant decreased （t=9.59, P＜0.01）.There were significant difference in plasmatic AVP of patients before and after clozapine treatment（t=2.37，P＜0.05）;No significant different was found in patients before and after chlorpromazine treatment(t=0.85, P＞0.05).Conclusions The results suggest that there are abnormal metabolism in plasmatic AVP of schizophrenic patients. The metabolism of AVP in schizophrenic patients may be influenced by treatment of some psychotropic drugs, such as clozapine.