精细与专用化学品
精細與專用化學品
정세여전용화학품
FINE AND SPECIALTY CHEMICALS
2011年
8期
11-13
,共3页
朱长松%黄斌%刘骏结%阳军%吉建飞%王明亮
硃長鬆%黃斌%劉駿結%暘軍%吉建飛%王明亮
주장송%황빈%류준결%양군%길건비%왕명량
马来酸二乙酯%迈克尔加成%环合%酰化%重排%抗倒酯
馬來痠二乙酯%邁剋爾加成%環閤%酰化%重排%抗倒酯
마래산이을지%매극이가성%배합%선화%중배%항도지
diethyl maleate%Michael addition%cyclization%acylation%rearrangement%trinexapac-ethyl
以丙酮和马来酸二乙酯为原料,经过迈克尔加成、环合、酰化及重排反应合成了抗倒酯,4步反应总收率63.4%。中间体及产品经~1HNMR和质谱表征。该方法具有操作简单、成本低、收率高等优点,适合工业化生产。
以丙酮和馬來痠二乙酯為原料,經過邁剋爾加成、環閤、酰化及重排反應閤成瞭抗倒酯,4步反應總收率63.4%。中間體及產品經~1HNMR和質譜錶徵。該方法具有操作簡單、成本低、收率高等優點,適閤工業化生產。
이병동화마래산이을지위원료,경과매극이가성、배합、선화급중배반응합성료항도지,4보반응총수솔63.4%。중간체급산품경~1HNMR화질보표정。해방법구유조작간단、성본저、수솔고등우점,괄합공업화생산。
Trinexapac-ethyl was synthesized by using acetone and diethyl maleate as the starting material via Michael addition,cyclization,acylation and rearrangement.The total yield of four steps was 63.4%.Structure of the product and intermediate was confirmed by ~1HNMR and MS.This method has many advantages,such as easy operation,low cost and high yield,which can be feasible to large scale preparation.
