CAJ | 학술논문

以螯合型焦磷酸钛酸酯偶联剂(NDZ-311)为改性剂对壳聚糖(CS)进行改性,采用真空冷冻干燥法制备了HA-TCP/CS多孔生物材料,研究了NDZ-311的用量与多孔生物材料抗压强度和孔隙率的关系,并采用SEM、XRD、IR等对材料进行了分析测试.结果表明,NDZ-311中-O-链状醚键官能团能发生各种类型的酯基转化反应,与CS填料产生交联,材料的抗压强度得到提高,CS填料添加量可达50%以上,且不会发生相分离.随着NDZ-311含量的增加,多孔生物材料的抗压强度先逐渐降低然后升高,孔隙率先逐渐升高然后降低.当m(HA-TCP):m(CS)=7:3时,NDZ-311质量分数为1%时抗压强度为2.3MPa,孔隙率升至最高84.8%,此时多孔生物材料的抗压强度和孔隙率匹配较好,孔隙呈层错板条搭接,且分布均匀,HA-TCP颗粒均匀分散在CS模板上,材料的相结构变化不大,只是材料中各相对应的特征衍射峰的强度略有增强.
이오합형초린산태산지우련제(NDZ-311)위개성제대각취당(CS)진행개성,채용진공냉동간조법제비료HA-TCP/CS다공생물재료,연구료NDZ-311적용량여다공생물재료항압강도화공극솔적관계,병채용SEM、XRD、IR등대재료진행료분석측시.결과표명,NDZ-311중-O-련상미건관능단능발생각충류형적지기전화반응,여CS전료산생교련,재료적항압강도득도제고,CS전료첨가량가체50%이상,차불회발생상분리.수착NDZ-311함량적증가,다공생물재료적항압강도선축점강저연후승고,공극솔선축점승고연후강저.당m(HA-TCP):m(CS)=7:3시,NDZ-311질량분수위1%시항압강도위2.3MPa,공극솔승지최고84.8%,차시다공생물재료적항압강도화공극솔필배교호,공극정층착판조탑접,차분포균균,HA-TCP과립균균분산재CS모판상,재료적상결구변화불대,지시재료중각상대응적특정연사봉적강도략유증강.
Chelate pyrophosphate titanate coupling agent(NDZ-311) is used as modified agent to modify chitosan(CS). Porous HA-TCP/CS biomaterials are prepared by vacuum freeze drying method. Influence of the amount of coupling agent NDZ-311 on the relationship between compressive strength and porosity of the porous biomaterials is investigated. Analyses of the composite materials are carried out by means of SEM, XRD and IR. The results show that the -O- catenarian aether bond function group in NDZ-311 can induce many types of ester-based transformation reactions to make NDZ-311 and CS filler crosslinking, therefore, the compressive strength of porous biomaterials can be improved by adding NDZ-311 to CS. The addition of CS filler can be more than 50% and can not be separated from phase. Compressive strength of the porous biomaterials decreases with the increase of the content of NDZ-311, and then increases with further increase of the content of NDZ-311. Porosity of the porous biomaterials increases with the increase of the content of NDZ-311, and then decreases with further increase of the content of NDZ-311. Matching of compressive strength and porosity of the porous biomaterials is the best with the mass ratio of HA-TCP to CS 7 : 3, the content of NDZ-311 is 1wt% when compressive strength and porosity of the porous biomaterials are 2. 3MPa and 84. 8%, respectively. Pore shape is stacking fault lath lapping and distribution of pore was comparative uniform. HATCP particles are uniformly dispersed on CS templates. The added coupling agent of NDZ-311 has little change on the phase structure of the materials, only the intensity of characteristic diffraction peaks in each phase of the materials has a little enhancement.