安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2009年
7期
767-769
,共3页
新生儿%克雷伯菌%肺炎%败血症%超广谱β-内酰胺酶%抗生素
新生兒%剋雷伯菌%肺炎%敗血癥%超廣譜β-內酰胺酶%抗生素
신생인%극뢰백균%폐염%패혈증%초엄보β-내선알매%항생소
neonatal%klebsiella pneumoniate%septicemia%ESBLs%antibiotic
目的 探讨院内感染新生儿肺炎克雷伯菌败血症的临床特征和药敏情况,为临床合理防治提供依据.方法 回顾分析我院新生儿科2005年5月至2008年9月间22例确诊为院内感染的肺炎克雷伯菌败血症患儿的临床资料、细菌药敏试验结果 .结果 早产、极低出生体重、使用广谱抗生素、侵入性操作多、住院时间长为肺炎克雷伯菌败血症的易感因素.22株肺炎克雷伯菌中产超广谱β-内酰胺酶(ESBLs)的菌株有16株(72.7%),对青霉素、头孢菌素类几乎全部耐药(敏感率为9.1%),对含酶抑制剂类药物、喹诺酮和氨基糖苷类抗生素敏感率较高(敏感率为63.6%～100%);对亚胺培南、美洛培南全部敏感(敏感率为100%).结论 新生儿科院内感染肺炎克雷伯菌败血症的发生存在易感因素.此类细菌绝大部分为产ESBLs菌株,亚胺培南、美洛培南为其首选药物.
目的 探討院內感染新生兒肺炎剋雷伯菌敗血癥的臨床特徵和藥敏情況,為臨床閤理防治提供依據.方法 迴顧分析我院新生兒科2005年5月至2008年9月間22例確診為院內感染的肺炎剋雷伯菌敗血癥患兒的臨床資料、細菌藥敏試驗結果 .結果 早產、極低齣生體重、使用廣譜抗生素、侵入性操作多、住院時間長為肺炎剋雷伯菌敗血癥的易感因素.22株肺炎剋雷伯菌中產超廣譜β-內酰胺酶(ESBLs)的菌株有16株(72.7%),對青黴素、頭孢菌素類幾乎全部耐藥(敏感率為9.1%),對含酶抑製劑類藥物、喹諾酮和氨基糖苷類抗生素敏感率較高(敏感率為63.6%～100%);對亞胺培南、美洛培南全部敏感(敏感率為100%).結論 新生兒科院內感染肺炎剋雷伯菌敗血癥的髮生存在易感因素.此類細菌絕大部分為產ESBLs菌株,亞胺培南、美洛培南為其首選藥物.
목적 탐토원내감염신생인폐염극뢰백균패혈증적림상특정화약민정황,위림상합리방치제공의거.방법 회고분석아원신생인과2005년5월지2008년9월간22례학진위원내감염적폐염극뢰백균패혈증환인적림상자료、세균약민시험결과 .결과 조산、겁저출생체중、사용엄보항생소、침입성조작다、주원시간장위폐염극뢰백균패혈증적역감인소.22주폐염극뢰백균중산초엄보β-내선알매(ESBLs)적균주유16주(72.7%),대청매소、두포균소류궤호전부내약(민감솔위9.1%),대함매억제제류약물、규낙동화안기당감류항생소민감솔교고(민감솔위63.6%～100%);대아알배남、미락배남전부민감(민감솔위100%).결론 신생인과원내감염폐염극뢰백균패혈증적발생존재역감인소.차류세균절대부분위산ESBLs균주,아알배남、미락배남위기수선약물.
Aim To study the clinical characteristics and the drug sensitivity of neonatal septicemia with nosocomial Klebsiella pneumoniate in order to provide the evidences for the prevention and treatment of this disease.Methods We retrospectively concluded all the 22 confirmed nosocomial cases of septicemia with K.Pneumonia in newborn infants of our hospital from May,2005 to September,2008,including their clinical characteristics and drug sensitivity results.Results The risk factors to cause nosocomial K.Pneumonia septicemia were prematurity,extremely low birth weight,use of broad-spectrum antibiotics,too much virulence operation and a longer mean length of stay.There were 16 strains which producing extended spectrum β-lactamase (ESBLs)among of the 22 strains(72.7%).It was found that almost all of the K.pneumoniae were resistant to penicillin and cephalosporins (the resistant rate was 90.9%),but were sensitive to penicillin and cephalosporins which bound enzyme inhibitor and quinolones and aminoside medicines(the sensitive rate was from 63.6% to 100%).All of the Klebsiella pneumoniate strains were sensitive to imipenem and meropenem(the sensitive rate was 100%).Conclusion There are risk factors in nosocomial cases of septicemia with K.Pneumonia in newborn infants.The main strains of the K.Pneumonia produced ESBLs,and imipenem or meropenem is the first choice.
