西安交通大学学报(英文版)
西安交通大學學報(英文版)
서안교통대학학보(영문판)
JOURNAL OF XI'AN MEDICAL UNIVERSITY
2004年
1期
82-84
,共3页
白艳红%慕慧%赵晏%蔡晓宏%王中秋%郭瑗
白豔紅%慕慧%趙晏%蔡曉宏%王中鞦%郭瑗
백염홍%모혜%조안%채효굉%왕중추%곽원
melatonin%human bladder carcinoma%anti-neoplasm
Objective To study the inhibitory effects of melatonin and its inhibitory mechanism on the growth of human bladder carcinoma T24. Methods The inhibitory effects of melatonin with various concentrations on the human bladder carcinoma T24 lines in vitro were determined by MTT assay. The mechanism of the inhibition was observed by flow cytometry (FCM) and transmission electron microscopy (TEM). Results The 30% inhibition concentration (IC30) value was 0.71mmol·L-1 and the 50% inhibition concentration (IC50) value was 1.20mmol·L-1. The population doubling time of T24 cells treated with melatonin at 0.71mmol·L-1 was 43.2 hours, which was significant different from that of 34.6 hours of the control group. Using FCM, we found that the cell percentage increased during the G1 phase, but decreased during the S stage. The degenerated ultra-structure of the cell treated with melatonin was also observed by TEM. Conclusion The results suggest that melatonin can inhibit the growth of human bladder carcinoma T24. The inhibitory effects of melatonin might be the prolonging of the staging from G1 to S in the cell cycle.