CAJ | 학술논문

目的：观察莪术水煎剂对未孕大鼠在体子宫肌电活动的影响并探讨其机制。方法：在一侧子宫浆膜面上埋植一对Ag-AgCl双极电极并联机记录，分别进行5种阻断剂使用前后莪术对子宫肌电活动影响的慢性实验。结果：莪术水煎剂可显著增加子宫肌电爆发波的峰面积、持续时间和爆发波的个数，且与剂量相关。腹腔注射阻断剂后，阿托品或酚妥拉明均明显减弱莪术对子宫肌电的兴奋效应，而其它3种阻断剂则无影响。结论：莪术对大鼠子宫肌电具有明显的兴奋作用，其兴奋作用与M受体和α受体有关。
목적：관찰아술수전제대미잉대서재체자궁기전활동적영향병탐토기궤제。방법：재일측자궁장막면상매식일대Ag-AgCl쌍겁전겁병련궤기록，분별진행5충조단제사용전후아술대자궁기전활동영향적만성실험。결과：아술수전제가현저증가자궁기전폭발파적봉면적、지속시간화폭발파적개수，차여제량상관。복강주사조단제후，아탁품혹분타랍명균명현감약아술대자궁기전적흥강효응，이기타3충조단제칙무영향。결론：아술대대서자궁기전구유명현적흥강작용，기흥강작용여M수체화α수체유관。
Objective: To investigate the effect of Curcuma zedoaria on the myoelectric activity of uterus in virgin rats and study its mech anisms. Method: A pair of bipolar Ag-AgCl electrodes were implanted on the serosal surface of uterus in rats to observe the effect of C. zedoaria on the myoelectric activity of uterus before and after the five agonists were injected intraperitoneally. Result: Decoction of C. zedoaria significantly increases the spike area, the duration and the number of bursts of action potentials of the uterine smooth muscle and its effect is related dosage. Atropine and phentolamine decreased the exciting effect of C. zedoaria, whereas verapamil,diphenhydramine and indomethacin have no effect on the excitation of C. zedoaria. Conclusion: C. zedoaria has obvious exciting effect on the smooth muscle of uterus in rats ,and its mechanisms may be associated with M-receptor and α-receptor.