CAJ | 학술논문

目的探讨2型糖尿病患者肿瘤坏死因子-α(Tumor necrosis factor-alpha TNF-α)血清浓度表达。方法测定85例2型糖尿病患者的血清TNF-α浓度、空腹血糖、基础胰岛素水平、血三酰甘油、血高密度脂蛋白-胆固醇(HDL-C)水平和肾功能，并以59例无糖尿病的冠心病患者作对照，并对相关资料作对比分析。结果血清TNF-α浓度在糖尿病组较非糖尿病组显著增高(P＜0.01)；糖尿病组中血清TNF-α浓度男女性别间无差异(P＞0.05)；与胰岛素作用指数(IAI)相关(r＜0.05)；血HDL-C水平与TNF-α浓度负相关(P＜0.05)。结论血清TNF-α浓度过度表达可能在胰岛素抵抗和2型糖尿病及其慢性并发症发病机制中起一定作用。
목적탐토2형당뇨병환자종류배사인자-α(Tumor necrosis factor-alpha TNF-α)혈청농도표체。방법측정85례2형당뇨병환자적혈청TNF-α농도、공복혈당、기출이도소수평、혈삼선감유、혈고밀도지단백-담고순(HDL-C)수평화신공능，병이59례무당뇨병적관심병환자작대조，병대상관자료작대비분석。결과혈청TNF-α농도재당뇨병조교비당뇨병조현저증고(P＜0.01)；당뇨병조중혈청TNF-α농도남녀성별간무차이(P＞0.05)；여이도소작용지수(IAI)상관(r＜0.05)；혈HDL-C수평여TNF-α농도부상관(P＜0.05)。결론혈청TNF-α농도과도표체가능재이도소저항화2형당뇨병급기만성병발증발병궤제중기일정작용。
Objective To investigate teh relationship between the serum concentration of tumor necrosis factoralpha and type 2 diabetes mellitus. Methods We analyzed the serum concentration of TNF-α, fasting plasma glucose (FPG), fasting plasma insulin(FINS), renal function and plasma lipids in 144 patients(59 with normal glucose tolerance and 85 type 2 diabetes mellitus). Results The serum concentration of TNF-α was significantly higher in type 2 diabetics than that in patients with normal glucose tolerance( P＜ 0.01 );there was no dilfference among the male and female diabetics( P ＞ 0.05); and there was a correlation between IAI(insulin action index) and serum TNF-α( P ＜ 0.05);moreover, HDL-C was inversely correlated with serum TNF-α concentration. Conclusion The results suggest that increased concentration of tumor necrosis factor-alpha may play a role in insulin resistance and the pathogenesis of ita comlications. (Shanghai Med J, 2001,24: 227-229)