CAJ | 학술논문

本工作进行了治疗用Na131I胶囊的研制及其性能评价。首先通过对失去不同结晶水及不同直径的Na2HPO4*12H2O吸附条件的研究得出：失结晶水越多，吸附量越大；晶体颗粒越小，吸附量越大。500 mg直径小于0.135 mm的无水Na2HPO4在0号胶囊中可吸附270 μL 0.05 mol/L NaOH溶液。吸附剂中加入1%的Vc,可减少131I的损失。胶囊的完全崩解时间为5 min，在30 d内20个样品的放射性都在平均值的96.5%～103.5%；样品的放射化学纯度>95%，核纯度>99%，均匀度和稳定性良好。动物实验结果表明，该胶囊无异常毒性；家兔甲状腺对治疗剂量的Na131I胶囊和Na131I液体在各时相的摄取率无差异。
본공작진행료치료용Na131I효낭적연제급기성능평개。수선통과대실거불동결정수급불동직경적Na2HPO4*12H2O흡부조건적연구득출：실결정수월다，흡부량월대；정체과립월소，흡부량월대。500 mg직경소우0.135 mm적무수Na2HPO4재0호효낭중가흡부270 μL 0.05 mol/L NaOH용액。흡부제중가입1%적Vc,가감소131I적손실。효낭적완전붕해시간위5 min，재30 d내20개양품적방사성도재평균치적96.5%～103.5%；양품적방사화학순도>95%，핵순도>99%，균균도화은정성량호。동물실험결과표명，해효낭무이상독성；가토갑상선대치료제량적Na131I효낭화Na131I액체재각시상적섭취솔무차이。
The preparation and property of Na131I therapeutic capsules are studied. The adsorption of different particle size Na2HPO4 with different crystallized water is investigated. The results indicate that the more the crystallized water, the less the adsorption; the small the particle size, the more the adsorption. The adsorbent amount of >110 mesh 500 mg anhydrous Na2HPO4 in No.0 capsule is 270 μL 0.05 mol/L NaOH solution. In order to prevent the volatility of radioiodide, 1% Vc should be included in adsorbent. The disintegrated time of capsule is 5 min. The radiochemical purity and nuclear purity of Na131I therapeutic capsule are over 95% and 99% respectively within 30 days after preparation. At the same time, the radioactivity of 20 capsules is in the range of 96.5%～103.5%. The animal experiments show that there is not extraordinary toxicity with Na131I therapeutic capsule, and no difference between Na131I therapeutic capsule and Na131I solution in rabbits thyroid uptake within 24 h.