CAJ | 학술논문

目的：研究糖皮质激素在交感神经系统和心血管活动调节中的作用。方法：细胞外记录头端延髓腹外侧区（RVLM）功能性质明确的前交感神经元自发放电；静脉注射皮质酮（50、10 0、150 μg/kg）观察前交感神经元放电频率的变化。结果：静脉注射不同剂量皮质酮后，12个RVLM前交感神经元的放电频率均较注射前明显增加（P<0.05），具有剂量依赖性，作用潜伏期为（104±25） s。结论：皮质酮能快速兴奋RVLM前交感神经元，提示糖皮质激素可能通过“快速膜效应”参与交感神经系统和心血管活动的调节。
목적：연구당피질격 소재교감신경계통화심혈관활동조절중적작용。방법：세포외기록두 단연수복외측구（RVLM）공능성질명학적전교감신경원자발방전；정맥주사피질동（50、10 0、150 μg/kg）관찰전교감신경원방전빈솔적변화。결과：정맥주사 불동제량피질동후，12개RVLM전교감신경원적방전빈솔균교주사전명현증가（P<0.05），구유제량의뢰성，작용잠복기위（104±25） s。결론：피질동능쾌 속흥강RVLM전교감신경원，제시당피질격소가능통과“쾌속막효응”삼여교감신경계통화심 혈관활동적조절。
Objective: To study the role of glucocorticoid i n the integration of sympathetic nervous system and cardiovascular activity. Methods: Neurons in the rostral ventrolateral medulla (RVLM) were extracelluarly recorded and identified as the presympathetic neurons of adult rats. The spontaneous discharge of the presympathetic neurons in the RVLM were observed by bolus intravenous injection of corticosterone (50, 100, 150 μg/kg） . Results: The firing rate of 12 presympathetic neurons was incr eased by intravenous application of corticosterone (P<0.05), and this effect showed a dose-dependent manner. The latency of excitatory effect was (104±2 5) s. Conclusion: Corticosterone can rapidly excite the presym pathetic neurons in the RVLM, this action might be involved in the integration o f sympathetic nervous system through the “rapid membrane effects”.