解剖科学进展
解剖科學進展
해부과학진전
PROGRESS OF ANATOMICAL SCIENCES
2001年
1期
4-6
,共3页
铝%学习记忆%突触界面结构%大鼠
鋁%學習記憶%突觸界麵結構%大鼠
려%학습기억%돌촉계면결구%대서
目的 探讨铝对大鼠学习记忆的影响及海马CA3区突触界面结构的变化。方法 采用电迷宫测试行为学反应，采用电镜技术及体视学方法研究突触界面结构。结果 实验组通过迷宫时间显著延长(P＜0.01)，同时伴随突触丢失，突触后膜致密物质变薄(P＜0.01)，细胞器有病理性改变。结论 铝可致学习记忆功能障碍，这一改变与突触可塑性密切相关。
目的 探討鋁對大鼠學習記憶的影響及海馬CA3區突觸界麵結構的變化。方法 採用電迷宮測試行為學反應，採用電鏡技術及體視學方法研究突觸界麵結構。結果 實驗組通過迷宮時間顯著延長(P＜0.01)，同時伴隨突觸丟失，突觸後膜緻密物質變薄(P＜0.01)，細胞器有病理性改變。結論 鋁可緻學習記憶功能障礙，這一改變與突觸可塑性密切相關。
목적 탐토려대대서학습기억적영향급해마CA3구돌촉계면결구적변화。방법 채용전미궁측시행위학반응，채용전경기술급체시학방법연구돌촉계면결구。결과 실험조통과미궁시간현저연장(P＜0.01)，동시반수돌촉주실，돌촉후막치밀물질변박(P＜0.01)，세포기유병이성개변。결론 려가치학습기억공능장애，저일개변여돌촉가소성밀절상관。
Objective To study the effect of aluminum on learning and memory and the synaptic interface constructure in hippocampus CA3 area in rats. Methods The electrical maze were used to test the behavioral reaction of rats. Some parameters of synaptic interface structure were measured by the method of ultrastructural quantitative analysis in hippocampus CA3 area in the rats. Results The time coming through the E-maze prolonged siginificantly in the experimental group compared with the normal control (P＜0.01), meanwhile the cyto-apparatus demonstrated the pathogenetic changes. Amounts of synapse obviously reduced and the post-synaptic density turned thinner in experimental group than in the control group (P＜0.01). Conclusion Aluminum can cause the malfunction on learning and memory, which related to the plastic of synapse.
