CAJ | 학술논문

目的：研究颅痛定(左旋四氢巴马汀，L-tetrahy-dropalmatine,L-THP)对缺氧后复氧早期心室肌细胞L-Ca电流的影响。方法：使用全细胞膜片钳技术研究心室肌细胞L-Ca电流的变化。结果：经20min的缺氧以及5min的复氧后，1，10，100(μmol.L-1)L-THP分别将ⅠCa-max电流从(675.75±107.07)pA减少至(645.46±108.75)pA、(492.08±72.84)pA、(376.60±71.35)pA，P值分别为＞0.05、＜0.05、＜0.01。结论：L-THP能有效地减少缺氧后复氧早期心室肌细胞L-Ca电流，这种作用无疑是其抗再灌注早期心律失常的电生理基础。
목적：연구로통정(좌선사경파마정，L-tetrahy-dropalmatine,L-THP)대결양후복양조기심실기세포L-Ca전류적영향。방법：사용전세포막편겸기술연구심실기세포L-Ca전류적변화。결과：경20min적결양이급5min적복양후，1，10，100(μmol.L-1)L-THP분별장ⅠCa-max전류종(675.75±107.07)pA감소지(645.46±108.75)pA、(492.08±72.84)pA、(376.60±71.35)pA，P치분별위＞0.05、＜0.05、＜0.01。결론：L-THP능유효지감소결양후복양조기심실기세포L-Ca전류，저충작용무의시기항재관주조기심률실상적전생리기출。
Objective:To investigate the effect of L-tetrahydropalmatine onL-Ca current in single ventricular myocyte of guinea pig during early reoxygenation. Method:The whole cell patch clamp technique was used to study the change of L-Ca current. Result:After 20 min deoxygenation and 5 min reoxygenation, L-tetrahydropalmatine reduced the I Ca-max from (675.75±107.07)pA to (645.46±108.75) pA(P＞0.05， n=6)，(492.08±72.84) pA(P＜0.05， n=6), (376.60±71.35) pA(P＜0.01, n=6)respectly. Conclusion:L-tetrahydropalmatine can significantly reduce the L-Ca current during early reoxygenation, which may contribute to its effect of anti-reperfusion arrhythmia.