生殖与避孕(英文版)
生殖與避孕(英文版)
생식여피잉(영문판)
REPRODUCTION & CONTRACEPTION
2001年
3期
162-166
,共5页
王芳%谭运年%陈碧%李英勇%康旭
王芳%譚運年%陳碧%李英勇%康旭
왕방%담운년%진벽%리영용%강욱
hydatidiform mole%c-Ha-fas oncogene%malignant transform%mutations
Objective To study the presence of c-Ha-fas oncogene mutations in hydatidiform mole (HM) tissues and to further explore its relationship with mole's malignancy Materials & methods c-Ha-ras codon 12 mutation was detected in invasive and noninvasive HM by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).Results c-Ha-fas codon 12 mutation was detected in 7 samples (53. 85%) of 13 invasive HM and 8 samples (26. 67%) in 30 non-invasive HM. c-Ha-ras mutations also showed loss of wild-type c-Ha-fas. No mutation in control group was observed.Conclusion The tendency of c-Ha-ras codon 12 mutation may be related with a higher invasive degree of HM.
