CAJ | 학술논문

迄今已有的细胞培养系统所存在的技术缺陷限制了对肾小管发生的分子生物学研究.最近,作者创建的Minu3D系统能产生完全可控制的生长条件,在此基础上,肾干细胞/祖先细胞能发育成结构清晰的肾小管.研究首次显示醛固酮能诱导形成肾小管.醛固酮可能通过启动某些盐皮质激素受体介导的胞内信号通路,从而启动和调节肾小管发生.该文讨论了近年来该领域的一些最新研究工作在揭示肾小管发生机制方面的意义.
흘금이유적세포배양계통소존재적기술결함한제료대신소관발생적분자생물학연구.최근,작자창건적Minu3D계통능산생완전가공제적생장조건,재차기출상,신간세포/조선세포능발육성결구청석적신소관.연구수차현시철고동능유도형성신소관.철고동가능통과계동모사염피질격소수체개도적포내신호통로,종이계동화조절신소관발생.해문토론료근년래해영역적일사최신연구공작재게시신소관발생궤제방면적의의.
The existing technical disadvantages of culture systems so far developed have limited the molecular biological study of tubulogenesis. Recently, a newly developed Minu3D system creates controllable growth conditions and allows the generation of tubules from renal stem/progenitor cells. It is for the first time indicated that aldosterone is able to induce the formation of tubules. Aldosterone may trigger some of mineralocorticoid receptor-mediated signaling'pathways for the initiation and the regulation of the tubulogenesis. The implication of these studies toward unveiling tubulogenesis is discussed.