中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2008年
24期
7-9
,共3页
李同霞%王军%潘伟%顾国容
李同霞%王軍%潘偉%顧國容
리동하%왕군%반위%고국용
腺苷脱氨酶%C反应蛋白质%干扰素Ⅱ型%胸膜炎
腺苷脫氨酶%C反應蛋白質%榦擾素Ⅱ型%胸膜炎
선감탈안매%C반응단백질%간우소Ⅱ형%흉막염
Adenosine deaminase%C-reactive protein%Interferon type Ⅱ%Pleurisy
目的 探讨血清腺苷脱氨酶(ADA)活性、CRP含量和IFN-γ含量联合检测对结核性胸膜炎的诊断价值.方法 检测59例结核性胸膜炎患者(结核组)、20例恶性胸水患者(恶性胸水组)以及12例其他渗出性胸水患者(其他组)胸水和血清中的ADA活性、CRP含量以及IFN-γ含量,经统计学处理后,评价各项指标诊断结核性胸膜炎的灵敏度、特异度及临床诊断符合率.结果 结核组胸水中ADA活性、CRP含量、IFN-γ含量分别为(50.98±13.07)U/L、(142.90±51.42)mg/L、(139.46±70.43)ng/L,与恶性胸水组和其他组比较差异均有统计学意义,P＜0.05或＜0.1.ADA以45 U/L为临界值,诊断结核性胸膜炎的灵敏度为80.4%,特异度为96.9%,临床诊断符合率为86.4%;CRP以110 mg/L为临界值,诊断结核性胸膜炎的灵敏度为78.6%,特异度为81.2%,临床诊断符合率为79.5%;IFN-γ以100 ng/L为临界值,诊断结核性胸膜炎的灵敏度为83.9%,特异度为93.8%,临床诊断符合率为87.5%.三项指标联合检测,诊断结核性胸膜炎的灵敏度为94.5%,特异度为97.8%,临床诊断符合率为94.3%.结论 ADA活性、IFN-γ含量和CRP含量联合检测可极大地提高结核性胸膜炎的诊断效能.
目的 探討血清腺苷脫氨酶(ADA)活性、CRP含量和IFN-γ含量聯閤檢測對結覈性胸膜炎的診斷價值.方法 檢測59例結覈性胸膜炎患者(結覈組)、20例噁性胸水患者(噁性胸水組)以及12例其他滲齣性胸水患者(其他組)胸水和血清中的ADA活性、CRP含量以及IFN-γ含量,經統計學處理後,評價各項指標診斷結覈性胸膜炎的靈敏度、特異度及臨床診斷符閤率.結果 結覈組胸水中ADA活性、CRP含量、IFN-γ含量分彆為(50.98±13.07)U/L、(142.90±51.42)mg/L、(139.46±70.43)ng/L,與噁性胸水組和其他組比較差異均有統計學意義,P＜0.05或＜0.1.ADA以45 U/L為臨界值,診斷結覈性胸膜炎的靈敏度為80.4%,特異度為96.9%,臨床診斷符閤率為86.4%;CRP以110 mg/L為臨界值,診斷結覈性胸膜炎的靈敏度為78.6%,特異度為81.2%,臨床診斷符閤率為79.5%;IFN-γ以100 ng/L為臨界值,診斷結覈性胸膜炎的靈敏度為83.9%,特異度為93.8%,臨床診斷符閤率為87.5%.三項指標聯閤檢測,診斷結覈性胸膜炎的靈敏度為94.5%,特異度為97.8%,臨床診斷符閤率為94.3%.結論 ADA活性、IFN-γ含量和CRP含量聯閤檢測可極大地提高結覈性胸膜炎的診斷效能.
목적 탐토혈청선감탈안매(ADA)활성、CRP함량화IFN-γ함량연합검측대결핵성흉막염적진단개치.방법 검측59례결핵성흉막염환자(결핵조)、20례악성흉수환자(악성흉수조)이급12례기타삼출성흉수환자(기타조)흉수화혈청중적ADA활성、CRP함량이급IFN-γ함량,경통계학처리후,평개각항지표진단결핵성흉막염적령민도、특이도급림상진단부합솔.결과 결핵조흉수중ADA활성、CRP함량、IFN-γ함량분별위(50.98±13.07)U/L、(142.90±51.42)mg/L、(139.46±70.43)ng/L,여악성흉수조화기타조비교차이균유통계학의의,P＜0.05혹＜0.1.ADA이45 U/L위림계치,진단결핵성흉막염적령민도위80.4%,특이도위96.9%,림상진단부합솔위86.4%;CRP이110 mg/L위림계치,진단결핵성흉막염적령민도위78.6%,특이도위81.2%,림상진단부합솔위79.5%;IFN-γ이100 ng/L위림계치,진단결핵성흉막염적령민도위83.9%,특이도위93.8%,림상진단부합솔위87.5%.삼항지표연합검측,진단결핵성흉막염적령민도위94.5%,특이도위97.8%,림상진단부합솔위94.3%.결론 ADA활성、IFN-γ함량화CRP함량연합검측가겁대지제고결핵성흉막염적진단효능.
Objective To explore the diagnostic values of adenosine deaminase (ADA) activity,C-readive protein (CRP) content and IFN-γ content for tuberculous pleurisy.Methods Fifty-nine cases with tuberettlous pleurisy,20 cases malignant tumor with pleural fluid and 12 cases of the other pleural fluid were studied,ADA activity,CRP content and IFN-γ content of pleurnl fluid and serum were detected in those patients.Results The pleural fluid activity of ADA[(50.98±13.07)U/L],content of CRP[(142.90±51.42)mg/L]and content of IFN-γ [(139.46±70.43)ng/L] in tuberculous pleurisy were significantly higher than those in malignant tumor and the other pleural fluid (P＜0.05 or＜0.01).When regarded 45 U/L as critical value of ADA in tnberculous pleurisy,the sensitive rate,special rate and clinical diagnose accordance rate were 80.4%,96.9%and 86.4%respectively,110,mg/L as critical value of CRP,they were 78.6%,81.2%,and 79.5% respectvely.100 ng/L as critical value of IFH-γ,they were 83.9%,93.8% and 87.5% respeelively.Combined detection of them in tuberculous pleurisy,the sensitive tale,specinl rate and clinical diagnose accordance rate were 94.5%,97.8% and 94.3% respectively.Conclusion Combined delection of ADA activity,CRP content and IFN-γ content in pleural fluid can improve the diagnosis of tuberculous pleurisy.
